Address	(Office): Rm 107A, Marine Science Laboratory, CUHK (Lab): Rm 107, Marine Science Laboratory, CUHK
Phone	(Office): (852) 3943 6133 (Lab): (852) 3943 6770
Fax	(852) 2603 5391
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Research Associate Professor, School of Life Sciences

Research Interests

•  Coral and Coral Reef Biology, Ecology and Ecophysiology
• Seaweed Ecology, Ecophysiology, Phylogeography and Applications
• Environmental and Functional Responses of Marine Ecosystems

Representative Publications 

• Chui, A.P.Y., Ang, P.O. 2010. Massive overgrow of coral recruits by barnacles in winter low-temperature conditions, Hong Kong, China. Coral Reefs 29: 1017.
• Cheang, C. C., Chu, K. H., Ang, P. O. 2010. Phylogeography of the marine macroalga Sargassum hemiphyllum (Phaeophyceae, Heterokontophyta) in northwestern Pacific. Mol. Ecol. 19:2933-2948.
• Cheang, C. C., Chu, K. H., Fujita, D., Yoshida, G., Hiraoka, M., Critchley, M., Choi, H.G., Duan, D.L., Seriwasa, Y. & Ang, P. O. 2010. Low genetic variability of Sargassum muticum (Yendo) Fensholt (Phaeophyceae) revealed by a global analysis of its native and introduced populations. J. Phycol. 46: 1063-1074.
• Figueroa, F.L., Israel A., Neori, A., Martinez, B., Malta, E.J., Ang, P., Inken, S., Marquardt, R., Abdala, R., Korbee, N. 2010. Effect of nutrient supply on photosynthesis and pigmentation to short-term stress (UV radiation) in Gracilaria conferta (Rhodophyta). Mar. Poll. Bull. 60: 1768–1778.
• Wang H., Chiu, L.M.C., Ooi, V.E.C., Ang, P.O. 2010. A potent antitumor polysaccharide from edible brown seaweed Hydroclathrus clathratus. Botanica Marina 53:265-274.
• Tam, T.W., Ang, P.O. 2009. Catastrophic regime shifts in coral communities exposed to physical disturbances: Simulation results from object-oriented 3-dimensional coral reef model. J. Theor. Biology 259: 193-208.
• Tam, T.W., Ang, P.O. 2009. Structures, dynamics and stability of reef fish assemblages in non-reefal coral communities in Hong Kong, China. Aquatic Conserv: Mar. Freshw. Ecosyst. 19: 301-321.
• Cheang, C.C., Chu, K.H., Ang, P.O. 2008. Morphological and genetic variations in the populations of Sargassum hemiphyllum (Phaeophyceae) in northwestern Pacific. J. Phycol. 44: 855-865.
• Tam, T.W., Ang, P.O. 2008. Repeated physical disturbances and the stability of sub-tropical coral communities in Hong Kong, China. Aquatic Conserv: Mar. Freshw. Ecosyst. 18: 1005–1024.
• Zhao, Fengjuan, Liu Fuli, Liu Jidong, Ang, P. O. Jr., Duan Delin. 2008. Genetic structure analysis of natural Sargassum muticum (Fucales, Phaeophyta) populations using RAPD and ISSR markers. J. Appl. Phycol. 20: 191-198.

Research Grants

• 2011-2013, GRF, Physiological Ecology of the Brown Alga Sargassum in NW Pacific. HK$ 1,044,000.
• 2010-2012, NSFC/RGC Joint Research Scheme, Potential Impacts of Global Climate Change and Environmental Deterioration on Coral Reefs in South China Sea. HK$ 688,200.
• 2009-2011, GRF, Phylogeography and Morphological Analysis of the Brown Alga Sargassum from the South China Sea (RGC Earmarked Grant), HK$ 783,967.
• 2008-2009, AFCD, Provision of Services on Research Collection and Study on Octocorals and Black Corals in Hong Kong Waters Extension (AFCD, HKSAR Government), HK$ 300,000.
• 2007-2009, NSFC/RGC Joint Research Scheme, Genetic and Propagation Study of Brown Algae Sargassum spp. HK$ 685,000.
• 2006-2008, AFCD, Provision of Services on Research Collection and Study on Octocorals and Black Corals in Hong Kong Waters (AFCD, HKSAR Government), HK$ 695,000.
• 2006-2007, Ocean Park Conservation Foundation, An Evaluation of the Effectiveness of Sha Chau and Lung Kwu Chau Marine Park (SLMP) as a Sanctuary for the Chinese White Dolphin (CWD) HK$ 138,000.

Professional Activities

• Editorial Board, Journal of Phycology
• Executive Council, Asia Pacific Phycological Association
• Executive Council, International Society for Applied Phycology
• Executive Council, Asia Pacific Marine Biotechnology Society
• Steering Committee, Asia Pacific Coral Reef Society
• Advisory Committee, Hong Kong Ocean Park Conservation Foundation 

Address	(Office): Rm 178, Science Centre South Block (Lab): Rm 193, Science Centre South Block
Phone	(Office): (852) 3943 4170 (Lab): (852) 3943 6118
Fax	(852) 2603 7246
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Professor, School of Life Sciences
• Director, Centre for Protein Science and Crystallography
  
• Assistant Dean (Student Affairs), Faculty of Sciences
• Fellow, Shaw College

Research Interests

• Structure-function studies of macromolecular assembly in pathogenic bacteria
  
• Structure-function studies of metabolic enzymes
  

Representative Publications

1. Lu, P., Zhang, H., Gao, Y., Jia, X., Liu, Z., Wang, D., Au, S.W.*, Zhang, Q.*(2022) Cryo-electron tomography reveals the roles of FliY in Helicobacter pylori flagellar motor assembly. mSphere 7(1):e0094421. 
2. Wang, K.*, Chan, Y.C., So, P.K., Liu, X., Feng, L., Cheung, W.T., Lee, S.S., Au, S.W.*(2021). Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7-hydroxyl bile acids. Lipid Res. 62:100074.
3. Lam, W. W., Sun, K., Zhang, H. & Au, S.W.*(2020) Crystal structure of flagellar export chaperone FliS in complex with flagellin and HP1076 of Helicobacter pylori. Front Microbiol. 11:787-
4. Zhang, K., Zhang, H., Li, S., Pintille, G., Mou, T.C., Gao, Y., Zhang, Q., van den Bedem, H., Schmid, M., Au, S.W.* & Chiu, W*. (2019) Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies near-atomic resolution. Proc Natl Acad Sci USA 116:6800-6805.
5. Lam, K.H., Xue, C., Sun, K., Zhang, H., Lam W.W.L., Zhu, Z., Ng, J.T.Y., Sause, W.E, Lertsethtakarn, P., Lau, K.F., Ottemann, K.M. & Au, S.W.*(2018) Three SpoA-domain proteins interact in the creation of the flagellar Type III secretion system of Helicobacter pylori. J Biol Chem 293:13961-73
6. Xue, C., Lam, K.H., Zhang, H., Sun, K., Lee, S.H., Chen, X. & Au, S.W.*(2018) Crystal structure of the FliF-FliG complex from Helicobacter pylori yields insight into the assembly of the motor MS-C ring in the bacterial flagellum. J Biol Chem 293:2066-2078.
7. Zhang, H., Lam, K.H., Lam, W.W.L., Wong, S.Y.Y., Chan, V.S.F. & Au, S.W.*(2017) A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori. Mol Microbiol 106:690-703.
8. Chen, X., Cheng, H.F., Zhou, J., Chan, C.Y., Lau, K.F., Tsui, S.K. & Au, S.W.*(2017) Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis. J Biol Chem 292:16880-16890.
9. Li, J., Lam, W.W., Lai, T.W. & Au, S.W.*(2017) Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K+ efflux. Biochemical and Biophysical Research Communications, 493:1115-1121.
10. Lam, H., Lam, W.W., Wong, J.Y., Chan, L.C., Kotaka, M., Ling, T.K., Jin, D.Y., Ottemann, K.M., & Au, S.W.*(2013). Structural basis of FliG-FliM interaction in Helicobacter pylori. Mol Microbiol 88(4), 798-812. (Selected for cover image)
11. Lam, H., Ip, W.S., Lam, Y.W., Chan, S.O., Ling, T.K., & Au, S.W.*(2012). Multiple conformations of the FliG C-terminal domain provide insight into flagellar motor switching. Structure 20(2), 315-325.
12. Lam, W., Woo, E.J., Kotaka, M., Tam, W.K., Leung, Y.C., Ling, T.K. & Au, S.W.*(2010). Molecular interaction of flagellar export chaperone FliS and cochaperone HP1076 in Helicobacter pylori. FASEB J 24(10), 4020-4032.

Honors and Awards

• Suffrage Science Heirloom, MRC London Institute of Medical Sciences (LMS), UK, 2014
• Croucher Foundation Postdoctoral Fellowship, 1998

Research Grants

* RGC General Research Fund (GRF)

• 2022/23: Structure-function study of C-terminal processing protease CtpA and its association with Cag type IV secretion system in Helicobacter pylori 
• 2019/20: Structural studies of vacuolating cytotoxin VacA from Helicobacter pylori
• 2018/19: Structure-function studies of ESX-5 associated PE/PPE proteins in Mycobacterium tuberculosis
• 2014/15: Molecular interactome and functional characterization of the Helicobacter pylori export chaperone FliS
• 2013/14: Dissecting the interactome of motor switch complex and the functional importance of FliG-VacA interaction in H. pylori
• 2012/13: Molecular basis of flagellar rotational switching: Structural study of FliF-FliG assembly
• 2010/11: Understanding the molecular architecture of motor switch complex in Helicobacter pylori
• 2006/07: Structural Characterization of Flagellar Export Chaperon FliS of Helicobacter Pylori
• 2005/06: Proteomic Approach for Specific Identification of SUMO Proteases Substrates
• 2004/05: Structural and Functional Studies of SUMO E3 Ligases and SUMO Specific Proteases
  
  

* Health and Medical Research Fund

• 2018/19: Study of the type VII secretion system in Mycobacterium tuberculosis
• 2017/18: Dissecting the Roles of PE-PPE Subsets in ESX-5 Duplicated Regions in Mycobacterium Tuberculosis
  
• 2014/15: Structure-based screening for G6PD stabilizers to overcome primaquine-induced hemolysis in anti-malaria treatment
• 2013/14: Role of HP1076 in type IV secretion pathway in H. pylori
• 2012/13: Generation of PE-PPE interactome of Mycobacterium tuberculosis

* NSFC/RGC Joint Research Scheme

• 2013/14: Structural studies of flagellar motor switch from H. pylori: A combination of X-ray crystallography and cryo-electron microscopy approaches

* NSFC-General Programme

• 2013/14: Stoichiometry analysis of flagellar motor switch complex in Helicobacter pylori

Professional Activities

• Treasurer, Federation of Asian and Oceanian Biochemists and Molecular Biology (FAOBMB), 2020-2022
• Academic Editor, PLoS One, 2014 - present
• Secretary, Hong Kong Society of Biochemistry and Molecular Biology (HKSBMB), 2007-2017

Address	(Office): Rm 509B, Mong Man Wai Building (Lab): Rm 509A, Mong Man Wai Building
Phone	(Office): (852) 3943 4021 (Lab): (852) 3943 8032
Fax	(852) 2603 7732
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	i. About Edwin Chan ii. News iii. Full Publication List

Education

Positions

• Director, School of Life Sciences
• Professor, School of Life Sciences
• Director, Laboratory of Drosophila Research
• Warden, Postgraduate Halls

Research Interests 

• Human disease modelling
• Cellular, genetic and biochemical analyses of RNA and protein toxicity in neurological diseases
• Therapeutic intervention of neurological diseases
• Inhibitor that combats neurodegenerative diseases [>>Video ]

Representative Publications

• Chen, Z.S., Ou, M., Taylor, S., Dafinca, R., Peng, S.I., Talbot, K.* and Chan, H.Y.E.* (2023) Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulate Wnt/b-catenin pathway in C9ALS/FTD. Nat. Commun. 14(1):8420
• An, Y., Chen, Z.S., Chan, H.Y.E.* and Ngo, J.C.K.* (2022) Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases. Nucl. Acids Res. 50(13), 7655-7668.
• Peng, S.I., Leong, L.I., Sun, J.K., Chen, Z.S., Chow, H.M. and Chan, H.Y.E.* (2022) A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities. Mol. Ther. Nucleic Acids 29, 102-115.
• Peng, S., Guo, P., Lin, X., An, Y., Sze, K.H., Lau, M.H.Y., Chen, Z.S., Wang, Q., Li, W., Sun, J.K., Ma, S.Y., Chan, T.F., Lau, K.F., Ngo, J.C.K., Kwan, K.M., Wong, C.H., Lam, S.L., Zimmerman, S.C., Tuccinardi, T., Zuo, Z., Au Yeung, H.Y., Chow, H.M. and Chan, H.Y.E.* (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. Proc. Natl. Acad. Sci. USA. 118(19) e2022940118
• Chen, Z.S., Huang, X., Talbot, K. and Chan, H.Y.E.* (2021) A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Cell Death Dis. 12(2):136
• Zhang, Q., An, Y., Chen, Z.S., Koon, A.C., Lau, K.F., Ngo, J.C.* and Chan, H.Y.E.* (2019) A peptidylic inhibitor for neutralizing r(GGGGCC)exp-associated neurodegeneration in C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Mol. Ther. Nucleic Acids 16, 172-185.
• Chen, Z.S., Li, L., Peng, S., Chen, F.M., Zhang, Q., An, Y., Lin, X., Li, W., Chan, T.F., Lau, K.F., Ngo, J.C., Wong, W.T., Kwan, K.M. and Chan, H.Y.E.* (2018) Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative diseases. EMBO Rep. 19, e45419
• Tsoi, H., Yu, A.C., Chen, Z.S., Ng, N.K., Chan, A.Y., Yuen, L.Y., Abrigo, J.M., Tsang, S.Y., Tsui, S.K., Tong, T.M., Lo, I.F., Lam, S.T., Mok, V.C, Wong, L.K., Ngo, C.K., Lau, K.F., Chan, T.F.* and Chan, H.Y.E.* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51, 590-595.
• Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.* and Li, M.* (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8, 98-108.
• Tsoi, H., Lau, C.K., Tsang, S.Y., Lau, K.F. and Chan, H.Y.E.* (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc. Natl. Acad. Sci. USA. 109, 13428-13433. 

Research Grants

• 2024-2026, Research Grants Council (RGC) GRF Grant, Investigating the heterozygous mutational effect of the CCDC88C gene on causing spinocerebellar ataxia, $1,592,000
• 2021-2022, Research Grants Council (RGC) GRF Grant, The role of adhesion molecule FasII/NCAM in synaptic dysfunction and neurodegeneration in myotonic dystrophy type I, $892,655
• 2020-2022, Research Grants Council (RGC) GRF Grant, How can we handle DNA damage induced by toxic RNAs?, $1,097,419
• 2019-2020, Research Grants Council (RGC) GRF Grant, Investigating the role of PAPD5 and its target microRNAs in RNA toxicity of polyglutamine diseases., $677,160
• 2016-2017, Research Grants Council (RGC) GRF Grant, Dissecting the regulatory mechanism of ubiquitin E3 ligase activity and understanding the importance of such regulation in polyglutamine pathogenesis., $768,202
• 2015-2019, The French National Research Agency (ANR)/Research Grants Council (RGC) Joint Research Scheme, Refining the bioactivity of P42, a hit therapeutic peptide, and developing a combined therapeutic peptide approach for treating Huntington’s Disease., $2,540,083
• 2015-2017, Research Grants Council (RGC) GRF Grant, Characterization of a novel pathogenic pathway of Huntington's Disease., $877,717
• 2014-2017, Research Grants Council (RGC) CRF Grant, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors., $7,044,220
• 2014-2016, Research Grants Council (RGC) GRF Grant, Characterization of a novel type of protein nuclear export signal in polyalanine expansion disease proteins., $866,032
• 2013-2015, Health and Medical Research Fund (HMRF) Grant, An inhibitory peptide approach to simultaneously target RNA and protein toxicities in polyglutamine degeneration., $999,908
• 2013-2015, Research Grants Council (RGC) GRF Grant, The role of nucleolin in CAG trinucleotide repeat-mediated RNA toxicity., $790,000
• 2009-2012, Research Grants Council (RGC) GRF Grant, Probing the nuclear transport role of the mutant polyglutamine domain in neurodegeneration., $929,247
• 2009-2011, Research Fund for the Control of Infectious Diseases Research (RFCID) Grant, Investigating the involvement of P13K/PDK-1/Akt pathways and Notch signals in SARS-CoV Membrane-induced apoptosis., $741,448
• 2009-2010, Cure Huntington’s Disease Initiative Foundation Early Discovery Initiative Fund, USA, Using the 3B5H10 Monoclonal Antibody to Investigate Huntingtin Oligomer and Toxicity in vivo., $444,149
• 2004-2007, Research Grants Council (RGC) Earmarked Grant, Nucleocytoplasmic transport and polyglutamine toxicity: A cellular genetic study., $1,265,677
• 2004-2006, Research Fund for the Control of Infectious Diseases Research (RFCID) Grant, Molecular and Genetic Characterization of the SARS Coronavirus Auxiliary Protein X1 in Drosophila., $675,144
• 2003-2007, Research Grants Council (RGC) Earmarked Grant, Genetic and proteomic studies of chaperone-mediated suppression of polyglutamine toxicity in Drosophila., $1,203,000

Patents

• Chan, H. Y. E.; Ngo, J. C.; Wong, C.; Zhang, Q.; Peng, S. Small molecule inhibitors targeting CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent US 10,143,666, Dec 4, 2018
• Chan, H.Y.E.; Ngo, J.C.; Zhang, Q. Peptidylic inhibitors targeting C9ORF72 hexanucleotide repeat-mediated neurodegeneration. U.S. Patent US-2018-0214515-A1, August 2, 2018
• Chan, H.Y.E.; Ngo, J.C.; Zhang, Q. Peptidylic inhibitor targeting CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent US-2017-0233442-A1, August 17, 2017
• Chan, H.Y.E.; Jensen, K.J.; Ngo, J.C.; Sorensen, K.K.; Zhang, Q.; Zuo, Z. P3 Peptidylic inhibitors for treating CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent 62/465,513, March 10, 2017
• Chan, H. Y. E.; Tsoi, H.; Ngo, J. C.; Lau, K. F. Therapeutic approach for polyglutamine degeneration. U.S. Patent US 9,297,798, March 29, 2016

Awards

• 2014 Churchill College Visiting By-Fellowship, University of Cambridge, UK
• 2011 Genetics Society of China Thirteenth Ju-Chi Li Animal Genetics Prize (第十三届李汝祺动物遗传学奖)
• The 2009 Young Researcher Award, The Chinese University of Hong Kong
• The 2009 Faculty Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong

 
Professional Activities

• Member, Public Education and Communication Committee, Society for Neuroscience, USA
• Council Member, Genetics Society of China
• Member, Biology and Medicine Panel (Joint Research Scheme), Research Grants Council (RGC) of Hong Kong
• Member, Ataxia Global Initiative, a worldwide multi-stakeholder research platform to systematically enhance trial-readiness in degenerative ataxias
• Associate Editor, Frontiers in Neurodegeneration
• Founding member, The Hong Kong Young Academy of Sciences
• Topic Editor, Frontiers in Cellular Neuroscience
• Editoral Board, Advances in Alzheimer's Disease
• Editoral Board, RNA & DISEASE
• Member, Scientific Advisory Committee, Society for Research on the Cerebellum

Others

• Session Chair (Models and Mechanism 1), Pan-Asian Consortium for Treatment and Research in ALS (PACTALS), Malaysia, 2023
• Co-Founder, Rare Power Limited
• Member, Charter of the Ataxia Global Initiative working group, Ataxia Global Initiative
• Member, Medical Advisory Board, Advancing CTNNB1 Cures and Treatments Inc.
• Member, Academic Committee of Asia Pacific Drosophila Neuroscience Conference, Academia Sinica, Taiwan, 2019
• Organizer, Inaugural Asia-Pacific Drosophila Neurobiology Conference, Wuhan, China, 2017
• Session Chair (Drosophila models for human diseases), 2nd Asia-Pacific Drosophila Research Conference, Seoul, Korea, 2013
• Chairperson, Scientific and Medical Advisory Committee, Hong Kong Spinocerebellar Ataxia Association, 2012 – present

Current Academic/Research Positions of Lab Alumni

• Dr. An Ying, Research Assistant Professor, School of Life Sciences, Southern University of Science and Technology, China
• Dr. Chan Kam Leung, Lecturer, School of Chinese Medicine, CUHK
• Dr. Chan Priscilla, Director of Research & Development (Healthcare), Nano and Advanced Materials Institute Limited, HK
• Dr. Chen Stephen, Postdoc Fellow, University of Oxford, UK
• Dr. Cheng Tat Cheung, CryoEM scientist, University of Gottingen, Germany
• Dr. Chuck Chi Pang, Research Scientist, Polytide Technology Inc., Canada
• Dr. Choi Ching Gee, Postdoc Fellow, HKU
• Professor Choi Jonathan, Professor, Department of Biomedical Engineering, CUHK
• Dr. Huen Macy, Manager, Technology Transfer and Commercialization, Intellectual Property Management, Hong Kong Polytechnic University
• Dr. Koon Alex Chun, Senior Lecturer, School of Life Sciences, CUHK
• Dr. Law Carman, Postdoc Fellow, City University of Hong Kong
• Dr. Li Li, Postdoc Fellow, College of Physics Science and Technology, Shenzhen University
• Dr. Ng Nelson, Senior Scientist, HUTCHMED
  
• Dr. Peng Isaac, Project Scientist, UC Irvine, USA
  
• Dr. Tsoi Ho Frankie, Research Assistant Professor, Department of Pathology, HKU
• Professor Wong Siu Lun Alan, Associate Professor, School of Biomedical Sciences, HKU
• Dr. Wu Chi Chung, Junior Group Leader, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University
• Dr. Zhang Qian, Clinical Trial Manager, Medpace, Bavaria, Germany
  
  

Address	(Office): Room 184, Science Centre South Block (Lab): Room 116, Run Run Shaw Science Building
Phone	(Office): (852) 3943 4420 (Mobile): (852) 9412 6791 (Lab): (852) 3943 1217
Fax	(852) 2603 5391
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.; This email address is being protected from spambots. You need JavaScript enabled to view it.
On-going projects	https://www.dropbox.com/s/8nsd3rnuu7i29kr/KMCHAN%20Research%20Projects%202017.pptx?dl=0

Education

Position

• Director, Environmental Science Program
• Associate Professor, School of Life Sciences
• Warden, Student Hostel 2, Shaw College

Research Interests

• Aquatic Toxicology
• Molecular Endocrinology
• Marine Biotechnology
• Environmental Policy  

Representative Publications

(out of 85 full papers in peer-reviewed international journals, 5 book chapters and over 168 abstracts or proceeding papers presented in international conferences; Hi Index 31 (19 since 2012), citations = 2460):

1. Chen, Y.Y., and Chan, K.M. (2018) Transcriptional inhibition of TCDD induced gene expression and protein expression profiles in zebrafish following the administrations of TCDD and cadmium. Toxicology Letters 282:121-135. (LINK)
2. Yang, J., Zhao, H., and Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47, and 99) and localization of BDE-99 induced cyp1 mRNA in zebrafish larvae. Toxicology Reports 4: 614-624. (LINK)
3. Zhou, Z., Yang, J., and Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquat. Toxicology 191: 175-188.
4. Tsang, Y.Y., Mack, C.W., Liebich, C., Lam, S.W., Sze, E. T-P., Chan, K.M. (2017) Microplastic pollution in marine waters and sediments of Hong Kong. Marine Pollution Bulletin 115:20-28.
5. Yang, J., Zhu, J., and Chan, K.M. (2016) BDE-99, but not BDE-47, is a transient aryl hydrocarbon receptor agonist in zebrafish liver cells. Toxicol. Appl. Pharmacol. 305: 203-215.
6. Chen, Y.Y., and Chan, K.M. (2016) Modulation of the expression of estrogen receptor pathway related genes by TCDD, Cd2+ and mixtures of Cd2+ and TCDD in zebrafish. Chemosphere 147: 467-476.
7. Yang, J., and Chan, K.M. (2015) Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Aq. Toxicol. 159:138-147.
8. Chen, Y.Y., Zhu, J.Y., and Chan, K.M. (2014) Effects of cadmium on cell proliferation, apoptosis, and proto-oncogene expression in zebrafish liver cells. Aq. Toxicol. 157: 196-206.
9. Leung, K.P., Chen, D.S., and Chan, K.M. (2014) Understanding copper sensitivity in zebrafish (Danio rerio) through tissue expression profiles and intracellular localization of copper transporters. Metallomics 6: 1057-1067.
10. Chan, W.K-L., and Chan, K.M. (2012) Effects of BDE-47, TBBPA and BPA on the hypothalamic-pituitary-thyroid axis in zebrafish embryo-larvae. Aq. Toxicol. 108:106-111.

Research Grants

• 1993-95, Cloning of growth hormone-like gene in economically important invertebrates, CUHK Research Committee Funding, HKD $100,000, BP92018.
• 1993, Bacterial expression of biosynthetic fish insulin-like growth factor, CUHK Research Committee Funding, HKD $ 25,700, MD92050.
• 1993-96, Somatolactin: studies on its expression in a bacterial system, its physiological functions and molecular mechanism of action in teleosts, Research Grant Council Earmarked Grant Funding, with Drs T.B. Ng and T.T. Chen., HKD $ 616,000, CUHK17/93M. Results ranked as SATISFACTORY by RGC.
• 1995-97, On the use of fish metallothionein levels as biomarker (I): development of sensitive immunoassay and polymerase chain reaction based assay to detect metallothionein gene expression in tilapia tissues, Research Grant Council Earmarked Grant Funding, HKD $ 682,000, CUHK355/95M. Results ranked as SATISFACTORY by RGC.
• 2004-06, Molecular mechanism of prolactin gene regulation in fish, Research Grant Council Earmarked Grant Funding, HKD $780,000, CUHK4410/04M. Results ranked as SATISFACTORY by RGC.
• 2006-07, Regulation of metallothionein gene expression in zebrafish, HKD $ 60,000, MD2041180.
• 2010-11, Molecular mechanism of copper ion intoxication- identification of copper-affected proteins relating to copper ion intoxication in tilapia and zebrafish, HKD $ 60,000, 2030425.
• 2014-15, Elucidating copper sensitivity of zebrafish by studying gene expression of copper transporters in vitro, HKD $ 60,000, 4053040.
• 2015-16, Toxic effects of brominated compounds on zebrafish, HKD 50,000, 3132779.
• 2016-17, Micro-Module Courseware Development Grant: Field Venture- Mobile Electronic Work Sheet for Field Study, HKD $91,000, 3210743. 

 Professional Activities

• American Fisheries Society, member since 1997
• Marine Biological Association of Hong Kong (Standing Committee member, 98-01), member since 1984
• Hong Kong Professional Teachers’ Union (Standing Committee member, 00-04; Secretary, 04- 06)
• Society of Environmental Toxicology and Chemistry (USA), full member 1989 - 2000
• Society of Toxicology (USA), full member since 1992 until now
• The American Physiological Society, full member 2007 - 2010
• Editorial Board Member: Bulletin of Environmental Contamination and Toxicology (since 2013)
• Editorial Board Member: Marine Environmental Research (since 2015)

Others

• 2004/05/06, Part-time member (appointed), Central Policy Unit, HKSAR Government
• 2005-Present, Advisor, Green Community
• 2005-2007, Member (elected in from a by-election), Higher Education Sub-Committee, Election Committee, HKSAR Government
• 2007-2011, Member (elected), Higher Education Sub-Committee, Election Committee, HKSAR Government (Resigned, December 2009)
• 2012-2017, Member (elected), Higher Education Sub-sector, Election Committee, HKSAR Government
• 2009-2019, Member (elected representative from Faculty of Science), Board of Trustees of Shaw College
• 2012-2014, Chairman (elected), Teachers’ Association of The Chinese University of Hong Kong (CUTA)
• 2014-2015, Secretary (elected), Teachers' Association of The Chinese University of Hong Kong (CUTA)
• 2015-17, President (elected), Teachers' Association of The Chinese University of Hong Kong (CUTA)