Address

(Office): Rm 507C, Mong Man Wai Building
(Lab): Rm 507D, Mong Man Wai Building

 People LLK
 

Phone

(Office): (852) 3943 8137
(Lab): (852) 3943 8072
Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web

http://www.bch.cuhk.edu.hk/lkleung/
 

 

 

Education

  Ph.D. in Nutritional Science, University of Kentucky
  M.Sc. in Food Science and Human Nutrition, University of Wyoming
  B.Sc. in Food Science, University of Alberta


Position

  • 1999 – present Assistant and Associate Professor, Food and Nutritional Sciences Programme,
    Chinese University of Hong Kong
  • 1995 – 1999 Postdoctoral Fellow, NCI-Frederick and University of Maryland


Research Interests

  •  Food Toxicology 


Representative Publications

(Total 66 journal articles & 8 abstracts)

  1. Li F, Wong TY, Lin S-M, Chow S, Cheung W-H, Chan FL, Chen S, Leung LK. (2014) Co-administrating luteolin minimizes the side effects of the aromatase inhibitor letrozole. Journal of Pharmacology and Experimental Therapeutic (accepted).
  2. Wong TY, Lin S-M, Poon CH, Leung LK. (2014) The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. Chemico-Biological Interactions Sep;221:70-76.
  3. Wang Y, Wong TY, Chan FL, Chen S, Leung LK. (2014) Assessing the effect of food myco-toxins on aromatase by using a cell-based system. Toxicology In Vitro Jun;28(4):640-6.
  4. Wong TY, Li F, Lin S-M, Chan FL, Chen S, Leung LK. (2014) Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. BMC Cancer Jun 12;14:426.
  5. Wang Y, Li L, Wang CC, Leung LK. (2013) Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae. Toxicology 314(1): 148–154.
  6. Tan W, Wong TY, Wang Y, Huang J, Leung LK. (2013) CYP19 Expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Molecular and Cellular Endocrinology 375(1-2):106-112.
  7. Tan W, Huang H, Wang Y, Wong TY, Wang CC, Leung LK. (2013) Bisphenol A differentially activates protein kinase C isoforms in murine placental tissue. Toxicology and Applied Pharmacology 269(2):163-168.
  8. Wang Y, Tan W, Leung LK. (2013) Zeranol upregulates corticotrophin-releasing hormone expression in the placental cell line JEG-3. Toxicology Letters 219(3):218-222.
  9. Li FJ, Chow S, Cheung W-H, Chan FL, Chen S, Leung LK. (2013) The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer. Journal of Nutritional Biochemistry Jun;24(6):1112-6.
  10. Poon CH, Wong TY, Wang Y, Tsuchiya Y, Nakajima M, Yokoi T, Leung LK. (2013)The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonizing XRE-binding. British Journal of Nutrition 109:1598-1605.


Research Grants

  • Establishing the Citrus Flavonoid Hesperetin as a Natural Alternative to Aromatase Inhibitor Direct Grants HK$38,742 Apr 30, 2011-Apr 30, 2012
  • Pharmacological properties of the licorice flavonoid isoliquiritigenin RGC Earmarked Grant HK$598,500 Jan 1, 2007-Dec 31, 2008


Professional Activities

Manuscript Reviewer
2003-present
Journal of Nutrition, British Journal of Nutrition, Toxicological Sciences, Toxicology in Vitro, BBA-Molecular Cell Research, Molecular Nutrition and Food Research, Nutrition and Cancer, Cancer Letters, BMC Cancer, Cell Biology and Toxicology, Journal of Pharmacy and Pharmacology, Journal of Agricultural and Food Chemistry, Journal of Food Biochemistry.

Grant Reviewer
2004-5, 2010 Cancer Research UK

 

 

Address

(Office): Rm 607, Mong Man Wai Building

(Lab): Rm 612B, Mong Man Wai Building

 People TSY
 

Phone

(Office): (852) 3943 1020

(Lab): (852) 3943 8071
Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

2003 Ph.D. Chinese University of Hong Kong
1999 B.Sc. Chinese University of Hong Kong (1st class honor)

Position

  • Professor, School of Life Sciences
  • Investigator, State Key Laboratory in Agrobiotechnology
  • Investigator, Ministry of Education (MOE) Key Laboratories for Regenerative Medicine
  • Investigator, Institute for Tissue Engineering and Regenerative Medicine (iTERM), CUHK
  • Program Director, Food and Nutritional Sciences Program, CUHK
  • Associate Dean of Students, United College, CUHK
  • Fellow, Assembly of Fellows, United College, CUHK 
  • Trustee, Board of Trustees, United College, CUHK

Research Interests

1. Embryonic stem cells and their cardiac derivatives:

a. Mechanisms for maintaining the self-renewal and pluripotent characteristics of embryonic stem cells.

b. Mechanisms controlling the cardiac differentiation of embryonic stem cells.

c. Mechanisms of automaticity of embryonic stem cell-derived cardiomyocytes.

2. Ion channels and cardiovascular physiology.

3. Adult stem cells and cancer stem cells.

Representative Publications

  • Liu X, Zhao R, Ding Q, Yao X, Tsang SY (2021) TRPC7 regulates the electrophysiological functions and structures of embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther. 12(1):262.
  • Zhao R, Liu X, Qi Z, Yao X, Tsang SY (2021) TRPV1 channels regulate the automaticity of embryonic stem cells-derived cardiomyocytes through stimulating the Na+/Ca2+ exchanger current. J Cell Physiol. Online ahead of print.
  • Chan HC, Lau YT, Ding Q, Li CK, Wong CM, Shaw PC, Waye MMY, Tsang SY (2020) PinX1t, a novel PinX1 transcript variant, positively regulates cardiogenesis of embryonic stem cells. J Am Heart Assoc. 9:e010240.  
  • Chan YW, So C, Yau KL, Chiu KC, Wang X, Chan FL, Tsang SY (2020). Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity. J Cell Physiol. 235:6794-6807.
  • Qi Z, Chen M, Song Y, Wang X, Chen ZF, Tsang SY *, and Cai Z* (2019) Acute exposure to Triphenyl Phosphate (TPHP) inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish. J Cell Physiol. 234(11):21235-21248.
  • Wang Y, Qi YX, Qi Z, Tsang SY (2019) TRPC3 regulates the proliferation and apoptosis resistance of triple negative breast cancer cells through the TRPC3/RASA4/MAPK pathway. Cancers. 11:558. 
  • Xu Y, So C, Lam HM, Fung MC, Tsang SY (2018) Apoptosis reversal promotes cancer stem-like cell formation. Neoplasia. 20:295-303.
  • Zhao R, and Tsang SY (2017) Versatile roles of intracellularly located TRPV1 channel. J Cell Physiol. 232:1957-65.
  • Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao XQ, Tsang SY (2016). TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int J Cardiol. 203:169-81.
  • Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY (2016) TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. 231:403-13.
  • Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao XQ, Tsang SY (2015). Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 10(7):e0133211.
  • Law SK, Leung CSL, Yau KL, Tse CL, Wong CK, Leung FP, Huang Y, Sauer H and Tsang SY (2013) Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J of Cardiol. 168:3458-72.
  • Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, Tsang SY (2012) Beta-sitosterol oxidation products attenuated vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Cardiovascular Res. 97:520-32.
  • Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY (2012) Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear factor of activated T-cells (NFAT). J Cell Physiol. 227:2519-30. (this article was selected to appear in the highlighted section)
  • Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY (2010) Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol. 224:165-77. (this article was selected to appear in the highlighted section)
  • Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111:11-20.
  • Tsang SY, Lesso H, Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. J Biol Chem 279:43752-9.
  • Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I, Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44:1-5.
  • Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M, Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke 35:1709-14.


Research Grants

  • 2021-2023, GRF, Role of TRPA1 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes through mediating mitochondrial biogenesis and/or dynamics, HKD $ 996,285
  • 2018-2020, GRF, The role of TRPC7 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes, HKD $ 854,494
  • 2017-2019, GRF, The role of TRPV1 channels in regulating the functions of embryonic stem cell-derived cardiomyocytes, HKD $ 893,792
  • 2014-2016, GRF, The role of Angiotensin II and the underlying mechanisms in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 744,788
  • 2013-2014, RGC Germany/Hong Kong Joint Research Scheme, Role of transient receptor potential (TRP) channels in mediating cardiotrophin-1-induced cardiac differentiation in embryonic stem cells, HKD $ 28,600
  • 2013-2014, GRF, The role of TRPC3 in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 650,000
  • 2012-2013, RGC Germany/Hong Kong Joint Research Scheme, Effects of Inflammatory Cytokines on the Cardiac Differentiation of Embryonic Stem Cells: Role of Reactive Oxygen Species, HKD$ 59,200
  • 2011-2014, GRF, Characterization of PinX1 and a novel truncated form of PinX1: their role in maintaining the characteristics of embryonic stem cells, HK$ 752,321
  • 2007-2011, GRF, Directed differentiation of human embryonic stem cells into cardiac lineage and the molecular mechanisms involved, HK$ 1,136,464
  • 2004-2006, Croucher Foundation, Genetic engineering of human embryonic stem cells to create a self-renewable ex vivo library of “custom-tailored” heart cells for transplantation, US$ 71,728


Awards

  • 2021, The Faculty Exemplary Teaching Award, CUHK
  • 2017, The Faculty Exemplary Teaching Award, CUHK
  • 2004-2006, The Croucher Foundation Fellowship

 

Professional Activities

 

Activities for Science Promotion

 

 

 

 

 

Address

(Office): Rm 177, Science Centre South Block
(Lab): Rm 113, Run Run Shaw Science Building

 People TFC
 

Phone

(Office): (852) 3943 6876
(Lab): (852) 3943 1216

Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.hkbic.cuhk.edu.hk/
 

 

Education

2003 Ph. D. Washington University School of Medicine
1997 B. Sc. University of Wisconsin-Madison

Position

  • Professor, School of Life Sciences
  • Co-director, Hong Kong Bioinformatics Centre
  • Associate Director, Molecular Biotechnology Programme, CUHK
  • Deputy Director, SKL Center for Soybean Research, CUHK
  • Deputy Director, RGC Area of Excellence (AoE) Center for Genomic Studies on Plant-Environment Interaction
  • Adjust Associate Professor, Hong Kong Institute of Diabetes and Obesity
  • Investigator, State Key Laboratory for Agrobiotechnology, CUHK

Research Interests

  • RNomics and bioinformatics in biological processes and diseases
  • Technology and algorithm development for genomics and transcriptomics

Representative Publications   * denotes corresponding author

  • Zhang J, Lin X, Chen Y, Li TH, Lee AC, Chow EY, Cho WC, Chan TF*. (2023) LAFITE reveals the complexity of transcript isoforms in subcellular fractions. Adv Sci. 10 (3), 2203480.
  • Zhao J, Chow EY, Yeung PY, Zhang QC, Chan TF*, Kwok CK*. (2022) Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0. BMC Biol. 20(1):257.
  • Chen Y, Wang Y, Chen Y, Cheng Y, Wei Y, Li Y, Wang J, Wei YY, Chan TF*, Li Y*. (2022) Deep autoencoder for interpretable tissue-adaptive deconvolution and cell-type-specific gene analysis. Nat Commun 13 (1), 1-17.
  • Yuan Y, Scheben A, Edwards D, Chan TF*. (2021) Towards haplotype studies in polyploid plants to assist breeding. Mol Plant 14 (12), 1969-1972.
  • Dumetz F, Chow EY, Harris LM, Umar MI, Jensen A, Chung B, Chan TF*, Merrick CJ*, Kwok CK*. (2021) G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum. Nucleic Acids Res. 49 (21), 12486-12501.
  • Jin N, Lee HM, Hou Y, Yu ACS, Li JW, Kong, AP, Lam CC, Wong SK, Ng EK, Ma RC, Chan JC*, Chan TF*. (2021) Integratome analysis of adipose tissues reveals abnormal epigenetic regulation of adipogenesis, inflammation and insulin signaling in obese individuals with type 2 diabetes. Clin Transl Med. 11(12): e596.
  • Lyu K, Chow EY, Mou X, Chan TF*, Kwok CK*. (2021) RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res. 49 (10), 5426-5450.
  • Lin X, Lin W, Ku YS, Wong FL, Li MW, Lam HM*, Ngai SM*, Chan TF* (2020) Analysis of soybean long non-coding RNAs reveals a subset of novel small peptide-coding transcripts. Plant Physiol 182(3):1359-74.
  • Xie M, Chung CY, Li MW, Wong FL, Wang X, Liu A, Wang Z, Leung AK, Wong TH, Tong SW, Xiao Z, Fan K, Ng MS, Qi X, Yang L, Deng T, He L, Chen L, Fu A, Ding Q, He JX, Chung G, Isobe S, Tanabata T, Valliyodan B, Nguyen HT, Cannon SB, Foyer CH, Chan TF*, Lam HM* (2019) A reference grade wild soybean genome. Nat Commun 10(1):1216.
  • Levy-Sakin M, Pastor S, Mostovoy Y, Li L, Leung AK, McCaffrey J, Young E, Lam ET, Hastie AR, Wong KH, Chung CY, Ma W, Sibert J, Rajagopalan R, Jin N, Chow EY, Chu C, Poon A, Lin C, Naguib A, Wang WP, Cao H, Chan TF#, Yip KY#, Xiao M#, Kwok PY#. (2019) Genome maps across 26 human populations reveal population-specific patterns of structural variation. Nat Commun 10(1):1025. (# Co-senior authors)

Research Grants

  • 2022-2026, NSFC/RGC Joint Research Scheme N_CUHK488/22, Unravelling fusarium wilt resistant gene(s) in Cavendish banana and exploring the underlying resistance mechanisms, $1,244,471.
  • 2022-2025, GRF14100422, A novel integrative method for the experimental identification and computational deconvolution of modifications at single RNA molecule resolution, $1,176,284.
  • 2019-2021, RGC Collaborative Research Fund C4057-18E, A nanochannel-based next-generation mapping system for the study of complex genomic feature and variation for biotechnological and biomedical applications (as PC), $2,173,431.
  • 2017-2025, UGC-Area of Excellence AoE/M-403/16, Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security (as co-PI and Deputy Director), $75,591,000.
  • 2014-2017, GRF14102014, Integrative analyses of RNA-sequencing, bioinformatics and biological studies to define cancer-associated long intergenic noncoding RNAs in hepatocellular carcinoma, $749,433.
  • 2014-2018, RGC Theme-based research T12-401/13R, Systematic development of molecular targets for nasopharyngeal carcinoma (as co-PI), $55,610,000.
  • 2011-2016, RGC Theme-based research T12-403/11, The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits (as co-PI), $45,000,000.
  • 2012-2015, GRF461712, In search of the missing heritability in complex diseases: whole transcriptome analysis of type 2 diabetes using a strand-specific RNA-sequencing approach, $784,020.
  • 2012-2014, HMRF 12110542, A single DNA molecule detection platform for pathogen typing and identification, $859,340.
  • 2011-2013, RFCID 11100512, Transcriptome analysis of the multidrug-resistant Acinetobacter baumannii by a strand-specific RNA-sequencing approach, $918,592.
  • 2011-2012, ITF UIM/206, A high performance computing solution to enable bioinformatics research, $1,142,180.
  • 2009-2011, GRF461809, Revisiting co-evolution theory of the genetic code from a whole-genome perspective: potential applications in synthetic biology, $709,264.
  • 2008-2011, GRF461708, Identification of genetic polymorphisms modulating natural variation in mRNA splicing in the human genome, $1,348,616.

Patents

  • Polynucleotide Barcoding; US Ser No. 10/976,546; USPTO Patent No. 7,829,278; Issued: Nov 09, 2010

Professional Activities

  • Associate Editor for Heliyon (Section Biochemistry, Molecular, and Cell Biology)
  • Associate Editor for The Plant Genome
  • Associate Editor for Frontiers in Genetics
  • Associate Editor for Frontiers in Ecology and Evolution
  • Member, The RNA Society
  • Member, The International Society for Computational Biology

 

 

Address

(Office): Rm G81, Science Centre South Block

(Lab): Rm G94&G84 Science Centre South Block

 People DJG
 

Phone

(Office): (852) 3943 6298

(Lab): (852) 3943 1258
Fax (852) 2603 5745
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -

 

Education

1998 Ph. D. Chinese Academy of Sciences
1994 M. Sc. Northeast Agricultural University
1991 B. Sc. Northeast Agricultural University

Position

  • Associate Professor, School of Life Sciences

Research Interests

 

  • Genomics and bioinformatics
  • Systems biology
  • Plant stress response
  • Plant secondary metabolism and trichome function

Representative Publications

  • Qing Zhang, Xiaodan Fan, Yejun Wang, Mingan Sun, Jianlin Shao, Dianjing Guo. BPP: a sequence-based algorithm for branch point prediction. 2017. Bioinformatics. (to appear)
  • Md. Mehedi Hasan, Mst. Shamima Khatun, Md. Nurul Haque Mollah, Cao Yong, and Guo Dianjing. A systematic identification of species-specific protein succinylation sites using joint element features information. 2017. Journal of Nanomedicine. (to appear)
  • Jue WANG, Yejun WANG; Caiji GAO; Liwen JIANG; Dianjing GUO. 2017. Plos One. PPero, a Computational Model for Plant PTS1 Type Peroxisomal Protein Prediction. https://doi.org/10.1371/journal.pone.0168912
  • Ming-an SUN, Yejun WANG, Qing ZHANG, Yiji XIA,Wei GE, and Dianjing GUO. Prediction of reversible disulfide based on features from local structural signatures. BMC Genomics. 2017.18(279). doi:  10.1186/s12864-017-3668-8.
  • Han Cheng, Haibin Cai, Haitian Fu, Zewei An, Jialin Fang, Yanshi Hu, Dianjing Guo, Huasun Huang. Functional Characterization of Hevea brasiliensis CRT/DRE Binding Factor 1 Gene Revealed Regulation Potential in the CBF Pathway of Tropical Perennial Tree. Plos One. 2015. https://doi.org/10.1371/journal.pone.0137634
  • Mingan Sun, Qing Zhang, Yejun Wang, Wei Ge, and Dianjing Guo.Prediction of redox-sensitive cysteines using sequential distance and other sequence-based features. 2016. BMC Bioinformatics. DOI: 10.1186/s12859-016-1185-4.
  • Zhang Yan and Dianjing Guo. Comparative Epigenetic Analyses of Acute and Chronic Leukemia. 2015. Journal of Biosciences and Medicines, 2015, 3, 29-35.
  • Chunqiang Li, Jiaofang Shao, Yejun Wang, Wenbin Li, Dianjing Guo, Bin Yan, Yiji Xia and Ming Peng. Analysis of banana transcriptome and global gene expression profiles in banana roots in response to infection by race 1 and tropical race 4 of Fusarium oxysporum f. sp. Cubense.   BMC   Genomics.   2013, 14:851 doi: 10.1186/1471-2164-14-851Q
  • Qing Zhang, X Fan, Y Wang, M Sun, SSM Sun, D Guo. A Model-Based Method for Gene Dependency Measurement. Plos One. 2012, 7(7): e40918. doi:10.1371/journal.pone.0040918
  • M Sun, Y Wang, H Cheng,Q Zhang,W Ge and D Guo. RedoxDB – a curated database for experimentally verified protein oxidative modification. Bioinformatics. 2012,28(19), p2551-2552.
  • Y Wang, H Huang, M Sun, Q Zhang and D Guo .T3DB: an integrated database for bacterial type III secretion system. BMC Bioinformatics. 2012, 13:66
  • Cheng H, Zhang Q, and Guo D. Genes respond to H2O2 are also evoked under light in Arabidopsis. Molecular Plant. 2012. Advance Access 10.1093/mp/sss108
  • Wang Y, Zhang Q, Sun M, Guo D: High-accuracy prediction of bacterial type III secreted (T3S) effectors based on position-specific amino acid composition profiles. Bioinformatics. 2011. 27(6):777-84. doi: 10.1093/bioinformatics/btr021

Research Grants

  • 2010-2013, GRF, Probing the molecular function of a bHLH protein in A.annua glandular trichome morphogenesis. HK$1,150,000
  • 2009-2012, GRF, Roles of two regulatory proteins in artemisinin metabolism and trichome function. HK$1,460,000
  • 2006-2009: An Integrated Functional Genomics Approach towards the Understanding of Artemisinin Metabolism. HK$1,052,500
  • 2006-2008: NSFC, Plant osmotic stress-response gene mining and functional analysis. RMB 260,000
  • 2007-2009. UGC Area of Excellence Scheme. AoE on Center for Plant and Agricultural Biotechnology-HK$25.0M (as co-I, PI: Prof. Samuel SM Sun)
  • 2005-2006: CUHK Direct grant, EST database approach for gene discovery in Artemisia annua glandular trichomes. HK$107,916

 

 

 

 

Address    (Office): G78B, Science Centre (South), CUHK
(Lab): G02/04, Run Run Shaw Science Building, CUHK 		                       People HJX 19 r1   
Phone   (Office): (852) 3943 6299
(Lab): (852) 3943 1271		    
Fax   (852) 2603 6382    
Email   This email address is being protected from spambots. You need JavaScript enabled to view it.     
ribbon

Education

1986 BSc, Lanzhou University
1989 M.Sc, Lanzhou University
1993 PhD, Lanzhou University


Position

  • Research Associate Professor, School of Life Sciences, CUHK
  • Investigator, State Key Laboratory of Agrobiotechnology, CUHK


Research Interests

  • Hormone signal transduction and signaling cross-talks in plants;
  • Plant stress resistance and application in agriculture


Representative Publications

  • Feng L, Teng F, Li N, Zhang JC, Zhang BJ, Tsai SN, Yue XL, Gu LF, Meng GH, Deng TQ, Tong SW, Wang CM, Li Y, Shi W, Zeng YL, Jiang YM, Yu W, Ngai SM, An LZ, Lam HM, He JX*. (2024) A reference-grade genome of the xerophyte Ammopiptanthus mongolicus highlights the evolution of legumes and its drought tolerance mechanisms. Plant Commun. 2024, doi: 10.1016/j.xplc.2024.100891. Epub ahead of print.
  • Li S, Yan J, Chen LG, Meng G, Zhou Y, Wang CM, Jiang L, Luo J, Jiang Y, Li QF, Tang W, He JX*. (2024) Brassinosteroid regulates stomatal development in etiolated cotyledons via transcription factors BZR1 and BES1. Plant Physiol. 2024 Feb 12:kiae068.
  • Xiao J, Zhou Y, Xie Y, Li T, Su X, He J, Jiang Y, Zhu H, Qu H. (2024) ATP homeostasis and signaling in plants. Plant Commun. 5(4):100834.
  • Lin Z, Zhu P, Gao L, Chen X, Li M, Wang Y, He J, Miao Y, Miao R. (2024) Recent advances in understanding the regulatory mechanism of plasma membrane H+-ATPase through the brassinosteroid signaling pathway. Plant Cell Physiol 2024 Feb 19:pcae014.
  • Zhang, S., Shan, Y., Li, Y., Zhang, J., He, J., Qu, H., Duan, X., & Jiang, Y. (2024) Role of hydrogen peroxide receptors in endocarp browning of postharvest longan fruit. Food Frontiers, 1–14.
  • Li, N., Wong, W.S., Feng, L., Wang, C.M., Wong, K.S., Zhang, N., Yang, W., Jiang, Y., Jiang., L., He, J.-X*. (2023) The thylakoid membrane protein NTA1 is an assembly factor of the cytochrome b6f complex essential for chloroplast development in Arabidopsis. Plant Commun. 4:100509. doi: 10.1016/j.xplc.2022.100509.
  • Feng L, Li Y, Zhou YL, Meng GH, Ji ZL, Lin WH, He JX *. (2023) Integrative Transcriptomic and Proteomic Analyses Reveal a Positive Role of BES1 in Salt Tolerance in Arabidopsis. Frontiers Plant Sci. 14:1034393.
  • Wu Q, Gao H, You Z, Zhang Z, Zhu H, He M, He J, Duan X, Jiang Y, Yun Z. (2023) Multiple metabolomics comparatively investigated the pulp breakdown of four dragon fruit cultivars during postharvest storage. Food Res Int. 164:112410.
  • Shan Y, Zhang S, Li Y, Zhang J, Farag, MA, He J-X, Xiao J, Qu H, Duan X, Jiang Y. (2023) The roles of exogenous ATP in postharvest fruit and vegetable: A systematic meta-analysis. Postharv Biol Technol, 199, 112305.
  • Zhang YJ, Zhang Y, Zhang LL, He JX, Xue HW, Wang JW, Lin WH*. (2022) OsGATA6 regulates rice heading date and grain number per panicle. J Exp Bot. 73:6133-6149.
  • Ji ZL, Yu MH, Ding YY, Li J, Zhu F, He JX*, and Li-Na Yang*. (2021) Coiled-Coil N21 of Hpa1 in Xanthomonas oryzae oryzae promotes plant growth, disease resistance and drought tolerance in non-hosts via eliciting HR and regulation of multiple defense response genes. Int. J. Mol. Sci. 22, 203.
  • Jiang G, Zeng J, Li Z, Song Y, Yan H, He J, Jiang Y, Duan X*. (2020) Redox regulation of the NOR transcription Factor is involved in the regulation of fruit ripening in tomato. Plant Physiol. 183: 671-685.
  • Xie M, Chung CY, Li MW, Wong FL, Wang X, Liu A, Wang Z, Leung AK, Wong TH, Tong SW, Xiao Z, Fan K, Ng MS, Qi X, Yang L, Deng T, He L, Chen L, Fu A, Ding Q, He JX et al. (2019). A reference-grade wild soybean genome. Nat Commun. 2019,10: 1216.
  • Yu M.-H., Zhao Z.-Z., He J.-X*. Brassinosteroid Signaling in Plant–Microbe Interactions. J. Mol. Sci. 2018, 19, 4091.
  • Li Q.F., Lu J., Yu J.W., Zhang C.Q., He J.X.*, Liu Q.Q.* (2018) The brassinosteroid-regulated transcription factors BZR1/BES1 function as a coordinator in multisignal-regulated plant growth. Biochim Biophys Acta Gene Regul Mech.1861: 561-571.
  • Kuang J.F., Chen J.Y., Liu X.C., Han Y.C., Xiao Y.Y., Shan W., Tang Y., Wu K.Q., He J.X.*, Lu W.J.* (2017) The transcriptional regulatory network mediated by banana (Musa acuminata) dehydration-responsive element binding (MaDREB) transcription factors in fruit ripening. New Phytol 21: 762-781.
  • Yang XY, Chen L, He JX*, Yu WC*. Knocking out of carotenoid catabolic genes in rice fails to boost carotenoid accumulation, but reveals a mutation in strigolactone biosynthesis. Plant Cell Rep. 2017, 36: 1533-1545
  • He J.X.* (2016) Signalling: Ying-yang hormonal crosstalk. Nature Plants 2, Article number: 16023. doi:10.1038/nplants.2016.23.
  • Li Q.F., He J.X.* (2016) BZR1 interacts with HY5 to mediate brassinosteroid- and light-regulated cotyledon opening in Arabidopsis in darkness. Mol Plant 9:113–125.
  • Zhang Y, Liu Z, Chen Y, He J*, Bi Y*. (2015) PHYTOCHROME-INTERACTING FACTOR 5 (PIF5) positively regulates dark-induced senescence and chlorophyll degradation in Arabidopsis. Plant Sci. 237:57-68.
  • Zhang Y., Liu Z., Wang J., Chen Y., Bi Y., He J.X.* (2015) Brassinosteroid is required for sugar promotion of hypocotyl elongation in Arabidopsis in darkness. Planta 242:881-893.
  • Yang X, Li J, Chen L, Louzada ES, He J*, Yu W*. Stable mitotic inheritance of rice minichromosomes in cell suspension cultures. Plant Cell Rep 34(6):929-41, 2015.
  • Wang X., Bian Y., Cheng K., Gu L.F., Ye M.L., Zou H.F., S.S.M. Sun and He J.X.* (2013) A Large-scale protein phosphorylation analysis reveals novel phosphorylation motifs and phosphoregulatory networks in Arabidopsis. J Proteomics 78:486-98.
  • Li Q.F., C Wang, L Jiang, S Li, S.S.M Sun*. and J.X. He*. (2012) An interaction between BZR1 and DELLAs mediates direct signaling crosstalk between brassinosteroids and gibberellins in Arabidopsis. Sci Signal 5:ra72. (Summary/Abstract/Reprint/FullText) (Highlight by Nature Reviews)
  • Jiang L, Y. Wang, Q.F. Li, L.O. Björn, J.X. He* and S.S. Li*. (2012) Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity. Cell Res 22:1046-1057. (Evaluated by Faculty 1000)
  • Wang X., Y.Y. Bian, K. Cheng, H.F. Zou*, S.S.M Sun* and J.X. He*. (2012) A comprehensive proteomic study of nitrogen deprivation in Arabidopsis reveals complex regulatory network of plant nitrogen responses. J Proteome Res 11:2301-2315.
  • Gampala, S.L., Kim, T.W., He, J.X., Tang, W.Q., Bai, M., Guan, S., Sun, Y., Gendron, J.M., Chen, J., Ferl, J., Ehrhardt, D., Chong, K., Burlingame, A.L., and Wang, Z.Y. (2007) An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell 13, 177–189.
  • He, J.X., Gendron, J.M., Sun, Y., Gampala, S.L., Gendron, N., Sun, C.Q., and Wang, Z.Y. (2005) BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science 307:1634-1638.
  • Wang, Z.Y. and He, J.X. (2004) Brassinosteroid signal transduction – choices of signals and receptors. Trends in Plant Sci 9: 91-96.
  • He, J.X., Fujioka, S., Li, T.C., Kang, S.G., Seto, H., Takatsuto, S.,Yoshida, S., and Jang, J.C. (2003) Sterols regulate development and gene expression in Arabidopsis. Plant Physiol 131:1258-1269.
  • He, J.X., JM Gendron, Y. Yang, J. Li, Z.Y. Wang. (2002) The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proc. Natl. Acad. Sci. USA 99:10185-90.


Research Grants

  • 2022-2024: Mechanistic study of an atypical plant U-box-like protein LPR in regulating primary root growth in Arabidopsis. RGC-GRF (Project code: 14104521), HK$1,125,732. (PI)
  • 2018-2019, 國家重點研發計劃—"港澳台科技創新合作” 重點專項，项目编号2017YFE0191100，RMB$980,000 (Co-PI)
  • 2018-2021: NSFC-RGC Joint Scheme. Mechanisms by which brassinosteroids regulate plant photomorphorgenesis through GATA and MYB transcription factors. (Project code: N_CUHK452/17), HK$1,250,000. (PI)
  • 2017-2025: Hong Kong UGC-AoE Grant, Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security. (Project code: AoE/M-403/16), HK$75.59 M. (Co-PI)
  • 2017-2019: Research Grant Council (RGC) GRF, Functional study of a new MYB-like transcription factor in secondary cell wall formation in Arabidopsis. (Project code: 14148916), HK$1,072,55. (PI)
  • 2016-2018: Research Grant Council (RGC) GRF, Characterization and gene functional study of a new albino mutant in Arabidopsis. (Project code: 14121915), HK$1,014,975. (PI)
  • 2014-2018: Hong Kong UGC-AoE Grant, Center for Organelle Biogenesis and Function. (Project code:  AoE/M-05/12), HK$47.25 M. (Co-I)
  • 2013-2015: Research Grant Council (RGC) GRF, Mechanistic studies of brassinosteroid-induced stress resistance in Arabidopsis. HK$1,200,000. (PI)
  • 2011-2013: Research Grant Council (RGC) GRF, Identify new regulators of brassinosteroid signaling and plant development through the bzr1-1D suppressor mutant screen in Arabidopsis. HK$1,000,000. (PI)
  • 2010-2012: Research Grant Council (RGC) GRF, Identify new downstream signaling components in the brassinosteroid signal transduction pathway in Arabidopsis - Functional characterization of two BZR1 interacting proteins ZIP1 and ZIP2. HK$944,700. (PI)
  • 2012-2015: National Science Foundation of China (NSFC), Genomic study of drought tolerance mechanisms in plants. RMB3.0M. (PI)
  • 2012-2016: Shenzhen ‘Peacock’ Project, Applied basic researches of plant molecular biotechnologies and their applications in modern agriculture. RMB30.0M. (Co-I, core member)
  • 2011-2013: National Science Foundation of China (NSFC), Functions and mechanisms of the Arabidopsis STO gene in plant UV-B signaling. RMB360,000. (Co-I)
  • 2009-2010: National Transgenic Project of China, Development of transgenic corn with high nitrogen use efficiency. RMB4.37M. (Sub-project PI)
  • 2009-2010: National Transgenic Project of China, Discovery and mechanistic study of genes important for crop yield, nutrition and stress resistance. RMB 2.96M. (Co-I)


Professional Activities

          Editorship:

  • Associate Editor, Frontiers in Plant Science (2021-)
  • Editorial Board Member, Acta Botanica Sinica (2009-).
  • Editorial Board Member/Reviewing Editor, Frontiers in Plant Science (2015-)
  • Editorial Board Member/Reviewing Editor, Scientific Reports (2016-)
  • Editorial Board Member/Reviewing Editor, Plant Science (2018-)
  • Editorial Board Member/Reviewing Editor, J of Plant Growth Regulation (2016-2017)

          Peer reviewer:

  • Nature Communications, Nature Plants, PNAS, Plant Cell, Plant Physiol, Mol Plant, Mol Cell Proteomics, Scientific Reports, Plant & Cell Environ, J Exp Bot, Frontiers in Plant Sci, Plant Science, J Genetics and Genomics (JGG), Plant Cell Reports, Planta, J Integr Plant Biol, Protoplasma, J Proteome Res, J Proteomics, PloS One, etc.

Other Impact

  • In 2022, Prof. JX He was listed among the world’s top 2% of the most cited scientists (single year citation category) by Stanford University.