Address

(Office): Room 603B, Mong Man Wai Building
(Lab): Room 611, Mong Man Wai Building

 People MC 

Phone

(Office): (852) 3943 1487
(Lab): (852) 3943 6162
Fax (852) 2603 5646
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web ---
 

 


Education

B.S. (Chemistry)  Harvey Mudd College, Claremont, CA
Ph.D. (Chemistry)  University of California, Berkeley, CA
Postdoctoral Fellow (Protein Crystallography)     California Institute of Technology, Pasadena, CA 


Positions

  • 1995-2001        Assistant Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
  • 2001-2005        Associate Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
  • 2005-2012        Professor of Chemistry/Biochemistry, The Ohio State University, Columbus, OH
  • 2010-2012        Interim-Chair of Biochemistry, The Ohio State University, Columbus, OH
  • 2012-2015        Director, School of Life Sciences, The Chinese University of Hong Kong
  • 2012- Present  Professor, School of Life Sciences, The Chinese University of Hong Kong


Research Interests

  • Chemical Biology -  We are working to capitalize on our discovery of pyrrolysine, the 22nd genetically-encoded amino acid, to engineer proteins with novel structures and properties.
  • Protein crystallography - We wish to use protein crystallography to elucidate the structure function relationships of proteins.
  • Protein Delivery -  We are exploring new technologies to deliver proteins to cells.

 Representative Publications

  1. Yekta, R.; Xiong, X.; Li, J.; Heater, B.S. Lee, M.M.; Chan, M.K.* “Mechano-responsive protein crystals for NADH recycling in multicycle enzyme reactions”, J Am Chem Soc, 2024, 146, 28, 18817. doi:10.1021/jacs.4c04725
  2. Xiong, X.; Heater, B.S.; Ho, W.Y.; Lee, H.K.; Lee, M.M.*; Chan, M.K.* "Genetically encoded multienzyme particles for the biosynthesis of putrescine from L-arginine" ACS Sustainable Chem Eng, 2024, 12, 2, 773–784. doi:10.1021/acssuschemeng.3c05247
  3. Zhang, W.; Yang, Z.; Zheng, J.; Fu, K.; Wong, J.H.; Ni, Y.; Ng, T.B.; Cho, C.H.; Chan, M.K.*; Lee, M.M.* “A bioresponsive genetically encoded antimicrobial crystal for the oral treatment of Helicobacter pylori infection”, Adv Sci, 2023, 10, 2301724. doi:10.1002/advs.202301724
  4. Tai, J.; Wang, L.; Chan, W.S.; Cheng, J.; Chan, Y.H.; Lee, M.M.*; Chan; M.K.* “Pyrrolysine-inspired in cellulo synthesis of an unnatural amino acid for facile macrocyclization of proteins”, J Am Chem Soc, 2023, 145, 18, 10249–10258. doi:10.1021/jacs.3c01291
  5. Li, J.; Kang, P.T.; Jiang, R.; Lee, J.Y.; Soares, J.A.; Krzycki, J.A.*; Chan; M.K.* “Insights from the structures of the pyrrolysine-containing trimethylaminemethyltransferase and its corrinoid protein complex”, Commun Biol, 2023, 16:54. doi:10.1038/s42003-022-04397-3
  6. Li, J.; Wang, L.; Kotaka, M.; Lee, M.M.; Chan; M.K.* "Insights from the structure of an active form of Bacillus thuringiensis Cry5B", Toxins, 2022, 14(12), 823. doi:10.3390/toxins14120823
  7. Yang, Z.; Sun, J.K.; Lee, M.M.*; Chan; M.K.* “Restoration of p53 activity via intracellular protein delivery sensitizes triple negative breast cancer to anti-PD-1 immunotherapy”, J ImmunoTher Cancer, 2022, 10:e005068. doi:10.1136/jitc-2022-005068
  8. Yang, Z.; Yang, M.; Chow, H.-M.; Tsang, S.Y.; Lee, M.M.*; Chan, M.K.* “Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy”, Acta Biomater, 2021, 135, 582-592. doi:10.1016/j.actbio.2021.08.054
  9. Yang, Z.; Lee, M.M.*; Chan, M.K.* “Efficient intracellular delivery of p53 protein by engineered protein crystals restores tumor suppressing function in vivo”, Biomaterials, 2021, 271:120759. doi.org/10.1016/j.biomaterials.2021.120759.
  10. Liang, Z.; Chan, H.Y.E.; Lee, M.M.*; Chan, M.K.* "A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation", Cell Chem Biol, 2021: 28, 180-90. doi:10.1016/j.chembiol.2020.12.010.
  11. Heater, B.S.; Yang, Z.; Lee, M.M.; Chan, M.K.* “In vivo enzyme entrapment in a protein crystal”, J Am Chem Soc, 2020, 142, 9879-9883. doi:10.1021/jacs.9b13462.
  12. Yang, Z.; Heater, B.S.; Cuddington, C.T.; Palmer, A.F.; Lee, M.M.M.*; Chan, M.K.* ”Targeted myoglobin delivery as a strategy for enhancing the sensitivity of hypoxic cancer cells to radiation”, iScience, 2020, 23, 101158. doi:10.1016/j.isci.2020.101158.
  13. Yang, Z.; Zheng, J.; Chan, C.-F.; Wong, I.L.K.; Heater, B.S.; Chow, L.M.C.; Lee, M.M.*; Chan, M.K.* “Targeted delivery of antimicrobial peptide by Cry protein crystal to treat intramacrophage infection”, Biomaterials, 2019, 217:119286. doi:10.1016/j.biomaterials.2019.119286.
  14. Heater, B.S.; Chan, W.S.; Lee, M.M.; Chan, M.K.* “Directed evolution of a genetically-encoded immobilized lipase for the efficient production of biodiesel from waste cooking oil”, Biotechnol Biofuels, 2019, 12: 165. doi:10.1186/s13068-019-1509-5.
  15. Li, X.*; Fekner, T.*; Ottesen, J.J.; Chan, M.K.* “A pyrrolysine analog for site-specific protein ubiquitination”, Angew Chem, 2009, 48, 9184-7.
  16. Fekner, T.; Li, X.; Lee, M.M.; Chan, M.K.* “A pyrrolysine analog for protein click chemistry”, Angew Chem, 2009, 48, 1633-5.
  17. Gong, W.*; Hao, B.*; Wei, Z.; Ferguson, D.J. Jr.; Tallant, T.; Krzycki, J.A.*; Chan, M.K.* “Structure of the CODH component of the M. barkeri ACDS complex”, Proc Natl Acad Sci USA, 2008, 105, 9558-63.
  18. Blight, S.K.; Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E. Zhao, G., Kang, P., Green-Church, K.B., Chan, M.K., Krzycki, J.A.* “Direct charging of tRNACUA with pyrrolysine in vitro and in vivo”, Nature, 2004, 431, 333-5. (cited in Nature, C&E News)
  19. Hao, B., Gong, W., Ferguson, T.K., James, C.M., Krzycki, J.A.*, Chan, M.K.* “Identification of novel UAG encoded residue: structure of a methanogen methyltransferase”, Science, 2002, 296, 1462-1466. (cited in C&E News, Nature, Science, CNN Headline News, Reuters)
  20. Gong, W.* Hao, B., Mansy, S.S., Gonzalez, G. Gilles-Gonzalez, M.A.*, Chan, M.K.* “Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction”, Proc. Natl. Acad. Sci. USA, 1998, 95, 15177-15182.


Research Grants

  1. 2024-2027, HKEX Research Funding Scheme (Co-I, PI: M.M. Lee), “Developing the next generation biocatalysts for the sustainable production of bio-based polyamide precursors towards the preservation of our natural environment”
  2. 2024-2025, Innovation and Technology Fund, “Facile synthesis and incorporation of proximity reactive amino acids for the generation of improved protein therapeutics”
  3. 2023-2024, Innovation and Technology Fund, “Pos3Aa platform-mediated Intracellular delivery of tumor suppressors to potentiate immunotherapy for immunologically cold tumors”
  4. 2022-2025, Health and Medical Research Fund (Co-I, PI: M.M. Lee), “Improving the therapeutic index of melittin to eradicate drug-resistant Acinetobacter baumannii”
  5. 2022-2025, Research Grants Council GRF, “In vivo synthesis and site-specific incorporation of pyrrolysine analogs for the facile generation of cyclic peptides and modified proteins”
  6. 2022-2024, Research Grants Council GRF, “Engineered Cry3Aa crystals for improved antimicrobial peptide delivery against intramacrophage infections”
  7. 2021-2024, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "Bioengineering arginine decarboxylase as a new therapeutic for cancer treatment”
  8. 2021-2023, Innovation and Technology Fund, “SUMO-derived peptide inhibitors for treating synucleinopathies”
  9. 2021-2023, Innovation and Technology Fund, (Co-I, PI: Y.P. Ho) “Development of a micro shear porator for loading red blood cells with therapeutic proteins”
  10. 2020-2022, Research Grants Council GRF, “Structural Studies of pyrrolysine-containing Methyltransferases”
  11. 2020-2021, Innovation and Technology Fund, “A versatile platform for generating recyclable catalysts for the production of biodiesel and commodity chemicals”
  12. 2019-2022, Research Grants Council GRF, “Genetically-encoded immobilized lipases for biofuel production”
  13. 2018-2021, Research Grants Council GRF, “Structural studies of nematicidal Cry proteins”
  14. 2017-2025, Research Grants Council AOE Grant (Co-PI, PI: Yang), “Chemical biology approach to molecular medicine”
  15. 2017-2019, Research Grants Council GRF, "Immobilized lipases for biodiesel conversion"
  16. 2016-2018, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "A novel anti-microbial crystal for the treatment of Helicobacter pylori infection"
  17. 2016-2019, Research Grants Council GRF, "Exploring the potential of myoglobin as an anti-cancer agent"
  18. 2015-2017, Health and Medical Research Fund, "Biological crystal subunit vaccines for mycobacterial diseases"
  19. 2015-2018, Research Grants Council GRF, “Studies of a copper peptide complex that can mediate methane oxidation”
  20. 2013-2015, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 10: “Novel dawadawa therapy for intestinal helminthic infections”
  21. 2012-2014, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 9: “A new system for dual bacterial/insecticidal crop protection”


Awards

Lando-SOHIO Fellowship, University of Minnesota (1984), Sigma Xi (1986), Phi-Lambda Upsilon (1986), Regents Fellowship, University of California (1986), Amoco Foundation Fellowship in Chemistry (1991), NIH Postdoctoral Fellowship (1992-1994), NSF Career Award (2000), Alfred P. Sloan Fellowship (2000), Member, NIH Study Section-BMT (2002-2006), Mr. and Mrs. Sun Chan Award in Organic Chemistry (2002), Visiting Scholar of the National Research Council of the Republic of China (2002), OSU College of Biological Sciences Award for Research and Graduate Education (2004), Visiting Scholar of the National Research Council of the Republic of China (2005, 2011), Japan Society for Promotion of Science Fellowship (2006), OSU Distinguished Scholar Award (2009), S. Y. Chung Visiting Fellow of New Asia College, CUHK (2010), Fellow of the American Association for the Advancement of Science (2011), Cynthia Anne Chan Memorial Lecturer, UC Berkeley (2011), RGC Physical Science Panel (2011, Chair 2012).


Others

We currently have openings for a postdoc having a degree from either a Hong Kong or Top 100 University. Those interested should contact us 3 months before the target start date.

We are also currently recruiting highly motivated graduate students with prior publications and/or exceptional academic records who are competitive for the Hong Kong Postgraduate fellowship Scheme. Please contact us by Nov 1 for consideration.

 

 

 

Address

(Office): Rm 384, Science Centre South Block
(Lab): LG 101 & 103, Run Run Shaw Science Building

 People JLW2 

Phone

(Office): (852) 3943 6388
(Lab): (852) 3943 6379
Fax (852) 2603 5745
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web

http://www.cuhk.edu.hk/centre/iCell/

http://www.cuhk.edu.hk/centre/ccdb/
   


Education

1996  Ph.D. Simon Fraser University
1992 M.Sc. University of British Columbia
1984 B.Sc. South China Agricultural University


Position

  • Choh-Ming Li Professor of Life Sciences, School of Life Sciences, CUHK
  • Director, Cell and Molecular Biology (CMB) Program, CUHK
  • Director, Centre for Cell and Developmental Biology, CUHK
  • Director, RGC-AoE "Centre for Organelle Biogenesis and Function", CUHK
  • Director, Institute of Plant Molecular Biology and Agricultural Biotechnology (IPMBAB), CUHK 


Research Interests

  • Plant Cell and Molecular Biology
  • Protein Targeting and Trafficking in Plant Cells
  • Organelle Biogenesis and Function in Plants
  • Plant Bioreactors for Pharmaceutical Proteins


Representative Publications

  1. Ye H, Gao J, Liang Z, Lin Y, Yu Q, Huang S and *Jiang L (2022) The Arabidopsis ORP2A Mediates ER-Autophagosomal Membrane Contact Sites and Regulates PI3P in Plant Autophagy. PNAS 119(43):e2205314119.
  2. Niu F, Ji C, Liang Z, Guo R, Chen Y, Zeng Y and *Jiang L (2022) ADP-ribosylation factor D1 modulates Golgi morphology, cell plate formation, and plant growth in Arabidopsis. Plant Physiology 190(2):1199-1213.
  3. He Y, Gao J, Luo M, Gao C, Lin Y, Wong HY, Cui Y, Zhuang X and *Jiang L (2022) VAMP724 and VAMP726 are involved in autophagosome formation in Arabidopsis thaliana. Autophagy (in press) doi: 10.1080/15548627.2022.2127240.
  4. Li B, Zeng Y, Lo SW, Guo Y and *Jiang L (2022) In vitro reconstitution of COPII vesicles from Arabidopsis thaliana suspension cultured cells. Nature Protocols (in press).
  5. Huang S, Liu Z, Cao W, Li H, Zhang W, Cui Y, Hu S, Luo M, Zhu Y, Zhao Q, Xie L, Gao C, Xiao S and *Jiang L (2022) The plant ESCRT component FREE1 regulates peroxisome-mediated turnover of lipid droplets in germinating Arabidopsis seedlings. Plant Cell (in press) doi: 10.1093/plcell/koac195.
  6. Cao W, Li Z, Huang S, Shi Y, Zhu Y, Lai MN, Lok PL, Wang X, Cui Y and *Jiang L (2022) Correlation of vacuole morphology with stomatal lineage development by whole-cell electron tomography. Plant Physiology 188(4):2085-2100.
  7. Li B, Zeng Y, Cao W, Zhang W, Cheng L, Yin H, Wu Q, Wang X, Huang Y, Lau WCY, Yao ZP, *Guo Y and *Jiang L (2021) A Distinct Giant COPII Vesicle Population in Arabidopsis thaliana. Nature Plants 7(10):1335-1346.
  8. * Zeng Y, Li B, Ji C, Feng L, Niu F, Deng C, Chen S, Lin Y, Cheung KCP, Wong KB and *Jiang L  (2021) A unique AtSar1D-AtRabD2a nexus modulates autophagosome biogenesis in Arabidopsis thaliana. PNAS 118(17):e2021293118.
  9. Lin Y, Zeng Y, Zhu Y, Shen J, Ye H and *Jiang L  (2021) Plant Rho GTPase signaling promotes autophagy. Molecular Plant 14(6):905-920.
  10. Liu Z, Gao J, Cui Y, Klumpe S, Erdmann PS and *Jiang L  (2021) Membrane Imaging in the Plant Endomembrane System. Plant Physiology 185:562-576.
  11. Ji CY, Zhou J, Guo R, Lin Y, Kung CH, Hu S, Ng WY, Zhuang XH and *Jiang L (2020) AtNBR1 is a selective autophagic receptor for AtExo70E2 in Arabidopsis. Plant Physiology 84(2):777-791.
  12. *Zhao Q, Shen J, Gao C, Cui Y, Wang Y, Cui J, Cheng L, Cao W, Zhu Y, Huang S, Zhou Q, Leong CK, Leung KP, Chen X and *Jiang L (2019) RST1 is a FREE1 suppressor that negatively regulates vacuolar trafficking in Arabidopsis. Plant Cell 31(9):2152-2168.
  13. Li H, Li Y, Zhao Q, Li T, Wei J, Li B, Shen W, Yang C, Zeng Y, Rodriguez P, Zhao Y, *Jiang L, *Wang X and *Gao C (2019) The Plant ESCRT Component FREE1 Shuttles to the Nucleus to Attenuate Abscisic Acid Signalling. Nature Plants 5(5):512-524.
  14. * Cui Y, Cao W, He Y, Zhao Q, Wakazaki M, Zhuang X, Gao J, Zeng Y, Gao C, Ding Y, Wong HY, Wong WS, Lam HK, Wang P, Ueda T, Rojas-Pierce M, Toyooka K, Kang BH and *Jiang L (2019) A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells. Nature Plants 5(1):95-105.
  15. *Shen J, Zhao Q, Wang X, Gao C, Zhu Y, Zeng Y and *Jiang L (2018) A Plant Bro1 Domain Protein BRAF Regulates Multivesicular Body Biogenesis and Membrane Protein Homeostasis. Nature Communications 9(1):3784.

Research Grants

  • 2022-2026, RGC Senior Research Fellow Scheme (SRFS), "Cellular and Molecular Characterization of the Tip-Vesicles in Germinating Pollen Tube", HK$ 7,798,380
  • 2021-2024, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “Vacuole Biogenesis, Dynamics and Functions in Plants” HK$ $6,400,000
  • 2020-2023, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong”, HK$7,439,308
  • 2019-2024, Research Grants Council (RGC) Research Impact Fund (RIF) as PI “Plant Bioreactor for Pharmaceutical Proteins”, HK$5,000,000
  • 2018-2021, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “Molecular Mechanisms of Autophagy and Autophagosome in Plants”, HK$7,209,550
  • 2017-2020, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “The First Integrated cryo-EM and cryo-ET Shared Facility for Life Sciences Research in Hong Kong”, HK $9,500,000
  • 2014-2021, Research Grants Council (RGC) Areas of Excellence Scheme (AoE) Grant as PC “Center for organelle biogenesis and function”, HK$47,250,000


Awards

  • 2021: RGC Senior Research Fellowship (2021/22)
  • 2017: Higher Education Outstanding Scientific Research Output Awards 2017 Second Class Prize, Ministry of Education of PRC
  • 2016: Research Excellence Award 2015-16, CUHK
  • 2015: Croucher Senior Research Fellowship 2015-2016, The Croucher Foundation
  • 2014: Choh-Ming Li Professor of Life Sciences, CUHK
  • 2014: Higher Education Outstanding Scientific Research Output Awards 2013 Second Class Prize, Ministry of Education of PRC
  • 2010: Higher Education Outstanding Scientific Research Output Awards 2009 First Class Prize, Ministry of Education of PRC
  • 2013: Outstanding Fellow of the Faculty of Science, CUHK
  • 2009: The Croucher Senior Research Fellowship 2009-2010
  • 2009: Research Excellence Award 2009-10, CUHK
  • 2008: Exemplary Teaching Award 2008, Faculty of Science, CUHK
  • 2006: Research Excellence Award 2006-07, CUHK


Professional Activities

  • Editor-in-Chief: Plant Science
  • Senior Editor: Journal of Integrative Plant Biology and 植物学报
  • Associate Editor: Protoplasma and Frontiers in Plant Science
  • Editorial Board: Plant Cell; Molecular Plant and 中國科學: 生命科學


Awards Received by Graduate Students and Postdoc

  • Young Scientist Award in Life Science, Hong Kong Institution of Science, 2021 (Li Baiying)
  • 1000 Young Talent Program of China, 2019 (Cui Yong)
  • 1000 Young Talent Program of Zhejiang, 2017 (Shen Jinbo)
  • 1000 Young Talent Program of China, 2015 (Ding Yu, Gao Caiji)
  • CUHK Young Scholars Thesis Award 2013 (Zhuang Xiaohong)
  • CUHK Young Scholars Dissertation Award 2013  (Shen Jinbo)
  • CUHK Young Scholars Dissertation Award 2009 (Miao Yansong)
  • Postgraduate Research Output Award 2016, CUHK (Zeng Allen)
  • Postgraduate Research Output Award 2013, CUHK (Shen Jinbo)
  • Postgraduate Research Output Award 2009, CUHK (Miao Yansong)
  • Postgraduate Research Output Award 2006, CUHK (Lam Sheung Kwan)
  • Postgraduate Research Output Award 2004, CUHK (Tse Yu Chung)
  • Research Fellowship Scheme 2018-2019, CUHK (Zeng Yonglun)
  • Research Fellowship Scheme 2017-2018, CUHK (Cui Yong)
  • Research Fellowship Scheme 2016-2017, CUHK (Cui Yong)
  • Research Fellowship Scheme 2015-2016, CUHK (Shen Jinbo)
  • Research Fellowship Scheme 2014-2015, CUHK (Zhuang Xiaohong)
  • Research Fellowship Scheme 2013-2014, CUHK (Ding Yu)
  • Keystone Symposium Scholarship 2012 (Wang Juan)
  • Keystone Symposium Scholarship 2007 (Miao Yansong)
  • The HFSP (Human Frontier Science Program) Long-Term Fellows 2010 (Lam Sheung Kwan)
  • The HFSP (Human Frontier Science Program) Long-Term Fellows 2009 (Miao Yansong)

Faculty Positions Lab Alumni

  • Hu Shuai, Associate Professor, Zhejiang Agriculture and Forestry University
  • Lau Wilson Chun Yu, Assistant Professor, CUHK
  • Cui Yong, Professor, Xiamen University
  • Zhao Qiong, Professor, East China Normal University
  • Shen Jinbo, Professor, Zhejiang Agriculture and Forestry University
  • Wang Xiangfeng, Associate Professor, China Agricultural University
  • Zhuang Xiaohong, Assistant Professor, CUHK
  • Wang Juan, Associate Professor, South China Agricultural University
  • Gao Caiji, Professor, South China Normal University
  • Ding Yu, Professor, Jinan University
  • Wang Hao, Professor, South China Agricultural University
  • Miao Yansong, Nanyang Assistant Professor, Nanyang Technological University
  • Cai Yi, Professor, Sichuan Agricultural University
  • Tse Yu Chung, Associate Professor, South University of Science and Technology of China
  • Wang Junqi, Associate Professor, South University of Science and Technology of China
  • Mo Beixin, Professor, Shenzhen University
  • Li Hongye, Professor, Jinan University

Address

(Office): Rm 138, Science Centre North Block
(Lab): --

 People PKS
 

Phone

(Office): (852) 3943 1393
(Lab): --
Fax

(852) 2603 6510
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web --
 

 

Education

Ph.D. Yale University
B.S. University of Washington

 

Position

  • Lecturer, School of Life Sciences


Research Interests

  • Immunology
  • Innate activation of adaptive immunity
  • Pathogen recognition by innate receptors
  • Influenza virus infection
  • Immune regulation by commensal bacteria


Representative Publications

  • Li L., Leung A.K., Kwok T.P., Lai Y.Y.Y., Pang I.K., Chung G.T., Mak A.C.Y., Poon A., Chu C., Li M., Wu J.J.K., Lam E.T., Cao H., Lin C., Sibert J., Yiu S.M., Xiao M., Lo K.W., Kwok P.Y., Chan T.F., Yip K.Y. (2017). OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps. Genome Biol. 18(1):230.
  • Schmid E.T., Pang I.K., Carrera Silva E.A., Bosurgi L., Miner J.J., Diamond M.S., Iwasaki A., Rothlin C.V. (2016). AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife. 5:e12414.
  • Pillai P.S., Molony R.D., Martinod K., Dong H., Pang I.K., Tal M.C., Solis A.G., Bielecki P., Mohanty S., Trentalange M., Homer R.J., Flavell R.A., Wagner D.D., Montgomery R.R., Shaw A.C., Staeheli P., Iwasaki A. (2016). Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 352(6284):463-6.
  • Pang, I.K., Pillai, P.S., and Iwasaki, A. (2013). Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I. Proc Natl Acad Sci U S A. 110(34), 13910-5.
  • Pang, I.K., Ichinohe, T., and Iwasaki, A. (2013). IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus. Nature immunology 14, 246-253.
  • Pang, I.K., and Iwasaki, A. (2012). Control of antiviral immunity by pattern recognition and the microbiome. Immunological Reviews 245, 209-226.
  • Ichinohe, T.*, Pang, I.K.*, Kumamoto, Y., Peaper, D.R., Ho, J.H., Murray, T.S., and Iwasaki, A. (2011). Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A 108(13), 5354-5359. *, authors contributed equally to this work
  • Pang, I.K., and Iwasaki, A. (2011). Inflammasomes as mediators of immunity against influenza virus. Trends in immunology 32, 34-41.
  • Ichinohe, T., Pang, I.K., and Iwasaki, A. (2010). Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nature immunology 11, 404-410.

 
Awards

  • Faculty Exemplary Teaching Award, Faculty of Science, CUHK, 2016
  • Distinguished Doctoral Dissertation, Yale University Graduate School of Arts and Sciences, 2013
  • Distinguished Speaker Award, Yale University Microbial Diversity Institute Symposium, 2012
  • Keystone Symposia Travel Scholarship, 2011
  • Amgen Scholars Alumni Travel Award, 2011

 
Professional Activities

  • Speaker, “Taking brakes off Immune System to attack Cancer”, Popular Science Special Lecture Series: How Nobel Prizes Are Won, Faculty of Science, CUHK, 2018
  • Speaker, “Ebola: The Micro-Killer”, The 11th Lau Oi Wah Memorial Science Lecture Series, Faculty of Science, CUHK, 2015
  • Invited Speaker, 6th HKU-Pasteur Immunology Course for Research Postgraduate Students, 2013
  • Invited Workshop Presenter, Keystone Symposia Conference on Pathogenesis of Influenza, 2011

 

 

Address

(Office): Rm 102A, Marine Science Laboratory
(Lab): Rm 102, Marine Science Laboratory

 People LHW 

Phone

(Office): (852) 3943 6121
(Lab): (852) 3943 6774
Fax ---
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.luolab.net
 

 

Education

2010 Ph.D (Molecular Evolution), University of South Carolina
2008 MSc (Marine Microbiology), University of South Carolina
2004 BSc (Environmental Science), Xiamen University

Positions

  • 2022.8 - pres Director, Simon F.S. Li Marine Science Laboratory, CUHK
  • 2021.1 - pres  Associate Professor, School of Life Sciences, CUHK
  • 2015.1 - 2020.12  Assistant Professor, School of Life Sciences, CUHK
  • 2010 - 2014  Postdoctorial Research Associate, University of Georgia

Research Interests

  • Microbial therapy for marine organisms
  • Endosymbiotic bacteria - marine host interaction
  • Genome evolution of marine bacterioplankton
  • Molecular clock and bacteria deep evolution
  • Terrestrial nitrogen-fixing bacteria

Representative Publications

  • S. Wang and H. Luo. 2024. Dating the bacterial tree of life based on ancient symbiosis. Systematic Biology (accepted)
  • H. Luo. 2025. How big is big? The effective population size of marine bacteria. Annual Review of Marine Science (in press)
  • T. Liao, S. Wang, H. Zhang, E.E. Stüeken, and H. Luo. 2024. Dating ammonia-oxidizing bacteria with abundant eukaryotic fossils. Molecular Biology and Evolution 41(5): msae096
  • H. Zhang, F.L. Hellweger, and H. Luo. 2024. Genome reduction occurred in early Prochlorococcus with an unusually low effective population size. The ISME Journal 18(1): wrad035
  • T. Liao, S. Wang, E.E. Stüeken, and H. Luo. 2022. Phylogenomic evidence for the origin of obligately anaerobic Anammox bacteria around the Great Oxidation Event. Molecular Biology and Evolution 39(8): msac170
  • X. Chu, X. Wang, L.S. Cheung, X. Feng, P. Ang, S.Y. Lee, S.A. Crowe, and H. Luo. 2022. Coastal transient niches shape the microdiversity pattern of a bacterioplankton population with reduced genomes. mBio 13(4): e00571-22
  • Z. Chen, X. Wang, Y. Song, Q. Zeng, Y. Zhang, and H. Luo. 2022. Prochlorococcus have low global mutation rate and small effective population size. Nature Ecology & Evolution 6(2): 183-194
  • H. Zhang, Y. Sun, Q. Zeng, S.A. Crowe, and H. Luo. 2021. Snowball Earth, population bottleneck and Prochlorococcus evolution. Proceedings of the Royal Society B 288(1963): 20211956
  • X. Feng, X. Chu, Y. Qian, M.W. Henson, V.C. Lanclos, F. Qin, S. Barnes, Y. Zhao, J.C. Thrash, and H. Luo. 2021. Mechanisms driving genome reduction of a novel Roseobacter lineage. The ISME Journal 15(12): 3576-3586
  • S. Wang and H. Luo. 2021. Dating Alphaproteobacteria evolution with eukaryotic fossils. Nature Communications 12: 3324
  • D. Luo, X. Wang, X. Feng, M. Tian, S. Wang, S-L. Tang, P. Ang, A. Yan, and H. Luo. 2021. Population differentiation of Rhodobacteraceae along coral compartments. The ISME Journal 15(11): 3286-3302
  • J. Tao, S. Wang, T. Liao, and H. Luo. 2021. Evolutionary origin and ecological implication of a unique nif island in free-living Bradyrhizobium lineages. The ISME Journal 15(11): 3195-3206
  • J. Gu, X. Wang, X. Ma, Y. Sun, X. Xiao, and H. Luo. 2021. Unexpectedly high mutation rate of a deep-sea hyperthermophilic anaerobic archaeon. The ISME Journal 15(6): 1862-1869
  • X. Chu, S. Li, S. Wang, D. Luo, and H. Luo. 2021. Gene loss through pseudogenization contributes to the ecological diversification of a generalist Roseobacter lineage. The ISME Journal 15 (2): 489-502

Research Grants

  • 01/2025-12/2027. General Research Fund, “A novel endosymbiotic Ruegeria species and its probiotic effects on corals” (14114724), PI, HK$1,559,580
  • 01/2024-12/2026. General Research Fund, “Understanding biological nitrogen cycle evolution through new molecular clock approaches” (14107823), PI, HK$1,374,820
  • 01/2023-12/2024. General Research Fund, “Timing the bacterial tree of life based on host-bacteria co-evolution” (14116922), PI, HK$1,081,749
  • 01/2023-06/2024. Marine Conservation Enhancement Fund, “Population genomics of coral-associated denitrifying bacteria along nitrate gradients in Hong Kong waters” (MCEF21101), PI, HK$790,650
  • 01/2021-12/2023. General Research Fund, “Reconstructing the evolutionary history of flavobacteria” (14110820), PI, HK$1,131,260
  • 01/2018-12/2020. General Research Fund, “Roseobacter genome content diversification in a heterogeneous ocean” (14163917), PI, HK$848,714
  • 06/2017-11/2019. Environment and Conservation Fund, “Genomic analysis of coral associated bacteria in Hong Kong waters” (15/2016), PI, HK$998,673
  • 01/2016-12/2018. Early Career Scheme, “Metabolism and evolution of uncultivated members of a generalist marine bacterial lineage” (24101015), PI, HK$1,067,343

Awards

  • 2017. CUHK Young Researcher Award
  • 2022. CUHK Research Excellence Award

Professional Activities

  • Book
    • Editor, Methods in Molecular Biology, Vol. 2569, Environmental Microbial Evolution: Methods and Protocols, 2022, Humana Press
  • Journal Editorship
    • Editorial Board member, The ISME Journal, 05/2020 - pres
    • Associate Editor, Computational and Structural Biotechnology Journal, 05/2023 - pres
    • Invited Guest Editor, Molecular Ecology, special issue “Genomics of Speciation”, 2024-2025