Professor SHAW Pang Chui

Address

(Office): Rm 180, Science Centre South Block

   People PCS 2 

Phone

(Office): (852) 3943 1363

  
Fax (852) 2603 7246  
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
  
Web  ---  
 

 

  

Education

1987 Ph.D. Imperial College, University of London
1983 M.Phil.. The Chinese University of Hong Kong
1981 B.Sc. The Chinese University of Hong Kong


Position

  • Research Professor, School of Life Sciences
  • Director, LDS YYC R & D Centre for Chinese Medicine
  • Deputy Director, Institute of Chinese Medicine
  • Master, Postgraduate Halls

 
Research Interests

  • Structure-function studies of proteins
  • Authentication, quality control and pharmacological studies of herbal material

Representative Publications

  1. Wang F, Tang YS, Cao F, Shou JW, Wong CK, Shaw PC. 3,4,5-tri-O-caffeoylquinic acid attenuates influenza A virus induced inflammation through Toll-like receptor 3/7 activated signaling pathway. Phytomedicine. 2024 Sep;132:155896. doi: 10.1016/j.phymed.2024.155896.
  2. Chan KT, Wu HY, Tin WY, But PP, Cheung SC, Shaw PC. Ethnopharmacology of five flowers herbal tea, a popular traditional beverage in Hong Kong and South China. J Ethnobiol Ethnomed. 2024 Mar 15;20(1):36. doi: 10.1186/s13002-024-00674-z.
  3. Wu HY, Wong KL, Law ST, Nong W, Chan KT, Hui JH, Lin G, Chan WH, Shaw PC. Determination of ITS1 haplotypes of Fritillariae Cirrhosae Bulbus by amplicon sequencing. Chin Med. 2024 Feb 28;19(1):33. doi: 10.1186/s13020-024-00911-3.
  4. Tang YS, Zhang C, Lo CY, Jin Z, Kong BL, Xiao MJ, Huang EF, Hu C, Shaw PC. Anti-influenza virus activities and mechanism of antrafenine analogs. Eur J Med Chem. 2023 Nov 15;260:115775. doi: 10.1016/j.ejmech.2023.115775.
  5. Shou JW, Shaw PC. Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma. Phytomedicine. 2023 Jul;115:154842. doi: 10.1016/j.phymed.2023.154842.
  6. Wang F, Kong BL, Tang YS, Lee HK, Shaw PC. Bioassay guided isolation of caffeoylquinic acids from the leaves of Ilex pubescens Hook. et Arn. and investigation of their anti-influenza mechanism. J Ethnopharmacol. 2023 Jun 12;309:116322. doi: 10.1016/j.jep.2023.116322.
  7. Xiao M, Zhang T, Cao F, Liang W, Yang Y, Huang T, Tang YS, Liu B, Zhao X, Shaw PC. Anti-influenza properties of tiliroside isolated from Hibiscus mutabilis L. J Ethnopharmacol. 2023 Mar 1;303:115918. doi: 10.1016/j.jep.2022.115918.
  8. Wu HY, Wong KH, Kong BL, Siu TY, But GW, Tsang SS, Lau DT, Shaw PC. Comparative Analysis of Chloroplast Genomes of Dalbergia Species for Identification and Phylogenetic Analysis. Plants (Basel). 2022 Apr 20;11(9):1109. doi: 10.3390/plants11091109.
  9. Kong BL, Nong W, Wong KH, Law ST, So WL, Chan JJ, Zhang J, Lau TD, Hui JH, Shaw PC. Chromosomal level genome of Ilex asprella and insight into antiviral triterpenoid pathway. Genomics. 2022 May;114(3):110366. doi: 10.1016/j.ygeno.2022.110366.
  10. Xiao M, Lim-Ho Kong B, Zhang Y, Yang Y, Lu J, Lee HK, Cao F, Shaw PC. Anti-influenza mechanism of phenolic phytochemicals from Canarium album (Lour.) DC. leaf extract. J Ethnopharmacol. 2022 Jun 28;292:115175. doi: 10.1016/j.jep.2022.115175.
  11. Shou JW, Shaw PC. Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms. Cells. 2022 Feb 24;11(5):796. doi: 10.3390/cells11050796.
  12. Shou JW, Li XX, Tang YS, Lim-Ho Kong B, Wu HY, Xiao MJ, Cheung CK, Shaw PC. Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPARδ for antioxidant action. Free Radic Biol Med. 2022 Mar;181:62-71. doi: 10.1016/j.freeradbiomed.2022.01.022.
  13. Tang YS, Xu S, Chen YW, Wang JH, Shaw PC. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021 Apr 19;49(7):4144-4154. doi: 10.1093/nar/gkab203.
  14. Yik MH, Wong VCT, Wong TH, Shaw PC. HerBChain, a blockchain-based informative platform for quality assurance and quality control of herbal products. J Tradit Complement Med. 2021 Jul 24;11(6):598-600. doi: 10.1016/j.jtcme.2021.07.005.

 
Books

  1. Shaw, P.C., Cao, H. and Lo, Y.T. (ed.) (2023) Authentication of Chinese Medicinal Materials by DNA Technology. 2nd ed. World Scientific Publishing Co. Ltd. Singapore.
  2. 曹暉、邵鵬柱、畢培曦主編(2016) 中藥分子鑒定 - 技術與應用。694頁。人民衛生出版社。
  1. 邵鵬柱、曹暉主編 (2004)中藥分子鑒定。329頁。復旦大學出版社。
  1. Shaw, P.C., Wang, J. and But, P.P.H. (ed.) (2002) Authentication of Chinese Medicinal Materials by DNA Technology. World Scientific Publishing Co. Ltd. Singapore. (The first international reference in this field of study)


Patents

  1. Investigation of the anti-obesity effect and mechanism of Tung Choi, a common vegetable Health and Medical Research Fund, 1/6/2024-30/11/26, HK$1,478,640)
  2. 運用多指標考察市場的容易混淆中藥材(Chinese Medicine Development Fund – Industry Support Programme B2, 1/8/2023-31/7/25, HK$1,904,280)
  3. Screening and characterization of anti-influenza virus components from Hong Kong Ilex species (Health and Medical Research Fund, 1/9/2020-28/2/23, HK$1,500,000)
  4. 邵鵬柱, 鄭永唐, 黃錦波, 羅嘉懿, 王睿睿, 麥雅絲.2013. 修飾的玉米核糖體失活蛋白前體及其應用和蛋白純化方法. 中國專利CN102234638.
  5. 邵鵬柱,畢培曦,徐宏喜,陳耀文,黃家樂. 2012. 用於鑒定有毒中藥材馬錢子品種的多核苷酸序列及其使用方法.中國專利CN10124537.
  6. But, P.P.H., Xu, Y.T., Shaw, P.C., Jiang, R.W. and Hon, P.M. (2011) Method of making antitussive medicine and relieving cough. US Patent No. 7,867,998.
  7. Shaw, P.C., Wang, J., But, P.P.H., Lau, T.W. (2004) The DNA sequences of medicinal Dendrobium and the application of these sequences for species identification and authentication. Chinese Patent ZL 01 1 02434.8.
  8. Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2003) Application of RFLP of DNA for the authentication of Chinese medicinal material. Chinese patent 98100001.0.
  9. Shaw, P.C., Wang, J., But, P.P.H., Ha, W.Y., Yau, F.C.F. (2004) Sequence characterized amplified region (SCAR) test for the authentication of traditional Chinese medicinal materials. US Patent No. 6,803,215.
  10. Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2001) Polymerase chain reaction-restriction fragment length polymorphism test for the authentication of herbal Chinese medicines. U.S. Patent No. 6,309,840.


Research Grants

  1. Investigation of the anti-obesity effect and mechanism of Tung Choi, a common vegetable (Health and Medical Research Fund, 1/6/2024-30/11/26, HK$1,478,640)
  2. 運用多指標考察市場的容易混淆中藥材(Chinese Medicine Development Fund – Industry Support Programme B2, 1/8/2023-31/7/25, HK$1,904,280)
  3. Screening and characterization of anti-influenza virus components from Hong Kong Ilex species (Health and Medical Research Fund, 1/9/2020-28/2/23, HK$1,500,000)
  4. Evaluation of anti-influenza properties of antrafenine and its analogs (Health and Medical Research Fund, 2019-22, HK$1,499,440)
  5. Molecular authentication of endangered timber samples – protocol development and evaluation on the scope of application (Environment and Conservation Fund, 2019-21, HK$1,290,562)
  6. Screening nickase enzyme candidates for the NGS technology designed by Genvida (Contract Research from Genvida (HK) Co. Ltd, 2019, $375,000)
  7. Evaluation of anti-influenza properties of antrafenine and its analogs (Health and Medical Research Fund, 2019-22, HK$1,499,440)
  8. Molecular authentication of endangered timber samples – protocol development and evaluation on the scope of application (Environment and Conservation Fund, 2019-21, HK$1,290,562)
  9. Screening nickase enzyme candidates for the NGS technology designed by Genvida (Contract Research from Genvida (HK) Co. Ltd, 2019, $375,000)
  10. Isolation and characterization of unique RNA-N glycosidases from mushroom (Research Grants Council, 2018-20, HK$1,229,089)
  11. Development of rapid screening protocol to identify shark fins from endangered species (Environment and Conservation Fund, 2016-18, HK$986,696)
  12. Isolation and characterization of unique RNA-N glycosidases from mushroom (Research Grants Council, 2018-20, HK$1,229,089)
  13. Development of rapid screening protocol to identify shark fins from endangered species (Environment and Conservation Fund, 2016-18, HK$986,696)
  14. Investigation of the antitussive effects of a folk medicine, cardiocrinum seeds. (Health and Medical Research Fund, 2015-17, $995,128)
  15. Study on the interaction of influenza A virus nucleoprotein and polymerase PB2 N-terminal region (Research Grants Council, 2015-17, $624,538)
  16. Establishment of new paradigm with feasible models in teaching and learning science for problem solving and future development (University Grants Committee, 2014-17, HK$10,000,000, as Co-PI)
  17. Structure-based drug design of anti-influenza compounds targeting influenza polymerase (Health and Medical Research Fund, 2014-16, $998,750)


Professional Activities

  • Editorial Board, Protein Engineering, Design and Selection
  • Co-Editor, Biodesign (Korea)
  • Editorial Board, Toxins (Basel)

 

Rankings

  • Named among world’s top 2% scientists by Stanford University (2023)
  • Ranked 297 by Research.com among scientists in the field of Biology and Biochemistry in China (2023)