Address	(Office): Rm 138, Science Centre North Block (Lab): --
Phone	(Office): (852) 3943 1393 (Lab): --
Fax	(852) 2603 6510
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	--

Education

Position

• Lecturer, School of Life Sciences

Research Interests

• Immunology
• Innate activation of adaptive immunity
• Pathogen recognition by innate receptors
• Influenza virus infection
• Immune regulation by commensal bacteria

Representative Publications

• Li L., Leung A.K., Kwok T.P., Lai Y.Y.Y., Pang I.K., Chung G.T., Mak A.C.Y., Poon A., Chu C., Li M., Wu J.J.K., Lam E.T., Cao H., Lin C., Sibert J., Yiu S.M., Xiao M., Lo K.W., Kwok P.Y., Chan T.F., Yip K.Y. (2017). OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps. Genome Biol. 18(1):230.
• Schmid E.T., Pang I.K., Carrera Silva E.A., Bosurgi L., Miner J.J., Diamond M.S., Iwasaki A., Rothlin C.V. (2016). AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife. 5:e12414.
• Pillai P.S., Molony R.D., Martinod K., Dong H., Pang I.K., Tal M.C., Solis A.G., Bielecki P., Mohanty S., Trentalange M., Homer R.J., Flavell R.A., Wagner D.D., Montgomery R.R., Shaw A.C., Staeheli P., Iwasaki A. (2016). Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 352(6284):463-6.
• Pang, I.K., Pillai, P.S., and Iwasaki, A. (2013). Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I. Proc Natl Acad Sci U S A. 110(34), 13910-5.
• Pang, I.K., Ichinohe, T., and Iwasaki, A. (2013). IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus. Nature immunology 14, 246-253.
• Pang, I.K., and Iwasaki, A. (2012). Control of antiviral immunity by pattern recognition and the microbiome. Immunological Reviews 245, 209-226.
• Ichinohe, T.*, Pang, I.K.*, Kumamoto, Y., Peaper, D.R., Ho, J.H., Murray, T.S., and Iwasaki, A. (2011). Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A 108(13), 5354-5359. *, authors contributed equally to this work
• Pang, I.K., and Iwasaki, A. (2011). Inflammasomes as mediators of immunity against influenza virus. Trends in immunology 32, 34-41.
• Ichinohe, T., Pang, I.K., and Iwasaki, A. (2010). Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nature immunology 11, 404-410.

 
Awards

• Faculty Exemplary Teaching Award, Faculty of Science, CUHK, 2016
• Distinguished Doctoral Dissertation, Yale University Graduate School of Arts and Sciences, 2013
• Distinguished Speaker Award, Yale University Microbial Diversity Institute Symposium, 2012
• Keystone Symposia Travel Scholarship, 2011
• Amgen Scholars Alumni Travel Award, 2011

 
Professional Activities

• Speaker, “Taking brakes off Immune System to attack Cancer”, Popular Science Special Lecture Series: How Nobel Prizes Are Won, Faculty of Science, CUHK, 2018
• Speaker, “Ebola: The Micro-Killer”, The 11^th Lau Oi Wah Memorial Science Lecture Series, Faculty of Science, CUHK, 2015
• Invited Speaker, 6^th HKU-Pasteur Immunology Course for Research Postgraduate Students, 2013
• Invited Workshop Presenter, Keystone Symposia Conference on Pathogenesis of Influenza, 2011

Address	(Office): Rm 102A, Marine Science Laboratory (Lab): Rm 102, Marine Science Laboratory
Phone	(Office): (852) 3943 6121 (Lab): (852) 3943 6774
Fax	---
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	http://www.luolab.net

Education

Positions

• 2022.8 - pres Director, Simon F.S. Li Marine Science Laboratory, CUHK
• 2021.1 - pres  Associate Professor, School of Life Sciences, CUHK
• 2015.1 - 2020.12  Assistant Professor, School of Life Sciences, CUHK
• 2010 - 2014  Postdoctorial Research Associate, University of Georgia

Research Interests

• Microbial therapy for marine organisms
  
• Endosymbiotic bacteria - marine host interaction
  
• Genome evolution of marine bacterioplankton
  
• Molecular clock and bacteria deep evolution
  
• Terrestrial nitrogen-fixing bacteria
  

Representative Publications

• S. Wang and H. Luo. 2024. Dating the bacterial tree of life based on ancient symbiosis. Systematic Biology (accepted)
• H. Luo. 2025. How big is big? The effective population size of marine bacteria. Annual Review of Marine Science (in press)
• T. Liao, S. Wang, H. Zhang, E.E. Stüeken, and H. Luo. 2024. Dating ammonia-oxidizing bacteria with abundant eukaryotic fossils. Molecular Biology and Evolution 41(5): msae096
• H. Zhang, F.L. Hellweger, and H. Luo. 2024. Genome reduction occurred in early Prochlorococcus with an unusually low effective population size. The ISME Journal 18(1): wrad035
• T. Liao, S. Wang, E.E. Stüeken, and H. Luo. 2022. Phylogenomic evidence for the origin of obligately anaerobic Anammox bacteria around the Great Oxidation Event. Molecular Biology and Evolution 39(8): msac170
• X. Chu, X. Wang, L.S. Cheung, X. Feng, P. Ang, S.Y. Lee, S.A. Crowe, and H. Luo. 2022. Coastal transient niches shape the microdiversity pattern of a bacterioplankton population with reduced genomes. mBio 13(4): e00571-22
• Z. Chen, X. Wang, Y. Song, Q. Zeng, Y. Zhang, and H. Luo. 2022. Prochlorococcus have low global mutation rate and small effective population size. Nature Ecology & Evolution 6(2): 183-194
• H. Zhang, Y. Sun, Q. Zeng, S.A. Crowe, and H. Luo. 2021. Snowball Earth, population bottleneck and Prochlorococcus evolution. Proceedings of the Royal Society B 288(1963): 20211956
• X. Feng, X. Chu, Y. Qian, M.W. Henson, V.C. Lanclos, F. Qin, S. Barnes, Y. Zhao, J.C. Thrash, and H. Luo. 2021. Mechanisms driving genome reduction of a novel Roseobacter lineage. The ISME Journal 15(12): 3576-3586
• S. Wang and H. Luo. 2021. Dating Alphaproteobacteria evolution with eukaryotic fossils. Nature Communications 12: 3324
• D. Luo, X. Wang, X. Feng, M. Tian, S. Wang, S-L. Tang, P. Ang, A. Yan, and H. Luo. 2021. Population differentiation of Rhodobacteraceae along coral compartments. The ISME Journal 15(11): 3286-3302
• J. Tao, S. Wang, T. Liao, and H. Luo. 2021. Evolutionary origin and ecological implication of a unique nif island in free-living Bradyrhizobium lineages. The ISME Journal 15(11): 3195-3206
• J. Gu, X. Wang, X. Ma, Y. Sun, X. Xiao, and H. Luo. 2021. Unexpectedly high mutation rate of a deep-sea hyperthermophilic anaerobic archaeon. The ISME Journal 15(6): 1862-1869
• X. Chu, S. Li, S. Wang, D. Luo, and H. Luo. 2021. Gene loss through pseudogenization contributes to the ecological diversification of a generalist Roseobacter lineage. The ISME Journal 15 (2): 489-502

Research Grants

• 01/2025-12/2027. General Research Fund, “A novel endosymbiotic Ruegeria species and its probiotic effects on corals” (14114724), PI, HK$1,559,580
• 01/2024-12/2026. General Research Fund, “Understanding biological nitrogen cycle evolution through new molecular clock approaches” (14107823), PI, HK$1,374,820
• 01/2023-12/2024. General Research Fund, “Timing the bacterial tree of life based on host-bacteria co-evolution” (14116922), PI, HK$1,081,749
• 01/2023-06/2024. Marine Conservation Enhancement Fund, “Population genomics of coral-associated denitrifying bacteria along nitrate gradients in Hong Kong waters” (MCEF21101), PI, HK$790,650
• 01/2021-12/2023. General Research Fund, “Reconstructing the evolutionary history of flavobacteria” (14110820), PI, HK$1,131,260
• 01/2018-12/2020. General Research Fund, “Roseobacter genome content diversification in a heterogeneous ocean” (14163917), PI, HK$848,714
• 06/2017-11/2019. Environment and Conservation Fund, “Genomic analysis of coral associated bacteria in Hong Kong waters” (15/2016), PI, HK$998,673
• 01/2016-12/2018. Early Career Scheme, “Metabolism and evolution of uncultivated members of a generalist marine bacterial lineage” (24101015), PI, HK$1,067,343

Awards

• 2017. CUHK Young Researcher Award
  
• 2022. CUHK Research Excellence Award

Professional Activities

• Book
• • Editor, Methods in Molecular Biology, Vol. 2569, Environmental Microbial Evolution: Methods and Protocols, 2022, Humana Press
• Journal Editorship
  
• • Editorial Board member, The ISME Journal, 05/2020 - pres
  • Associate Editor, Computational and Structural Biotechnology Journal, 05/2023 - pres
  • Invited Guest Editor, Molecular Ecology, special issue “Genomics of Speciation”, 2024-2025

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Address:	School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Phone:	(852) 3943 6799
Fax:	(852) 2603 5123
Email:	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web:	http://www.bch.cuhk.edu.hk/skkong

Education

Position

• Emeritus Professor, School of Life Sciences
• Adjunct Professor, School of Life Sciences
  
  

Research Interests

• Cancer Biochemistry - Mitochondria as Regulators of Cell Death
  
• Biosensor and Assay Development
  
• Eryptosis in Human Red Blodd Cells
  
  

Representative Publications 

• Yeung KW, Lau PM, Tsang HL, Ho HP, Kwan YW, Kong SK. (2019) Extracellular Histones Induced Eryptotic Death in Human Erythrocytes. Cell Physiol Biochem, 53:229-241.
• Wang S, Liu Y, Zhang D, Chen SC, Kong SK, Hu M, Cao Y, He H. (2018) Photoactivation of extracellular-signal-regulated kinase signaling in target cells by femtosecond laser. Laser & Photonics Review, 14/5/2018 https://doi.org/10.1002/lpor.201700137 
• Loo JF, Yang C, Tsang HL, Lau PM, Yong KT, Ho HP, Kong SK. (2017) An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening. Analyst, 142:3579-3587.
• Loo JF, Kwok HC, Leung CC, Wu SY, Law IL, Cheung YK, Cheung YY, Chin ML, Kwan P, Hui M, Kong SK, Ho HP. (2016) Sample-to-answer on molecular diagnosis of bacterial infection using integrated lab-on-a-disc. Biosens Bioelectron, 93:212-219. 
• Chen J, Kang Z, Wang G, Loo JF, Kong SK, Ho HP. (2015) Optofluidic guiding, valving, switching and mixing based on plasmonic heating in a random gold nanoisland substrate. Lab Chip, 15:2504-2512.
• Gao M, Lau PM, Kong SK. (2014) Mitochondrial toxin betulinic acid induces in vitro eryptosis in human red blood cells through membrane permeabilization. Arch Toxicol, 88:755-768.   
  
  

Research Grants

• 2008 GRF (PI), Suppression of caspase 3 by a novel non-coding RNA CUDR: A miRNA perspective. HKD $1,080,520.
• 2009 GRF (PI), The oncogenic pathway of riboregulator H19: From microRNA to DNA methylation. HKD $1,265,000.
• 2010 GRF (PI), To develop an aptamer-based surface plasmon resonance biosensor to detect apoptosis for anti-cancer drug discovery. HKD 983,753.
• 2012 GRF (PI), To develop a aicrofluidic device for testing allergy. HKD 724,500.
• 2012 GRF (Co-I), Tendon-derived Stem Cells (TDSCs) for tendon repair – A novel approach to clinical application. HKD 808,500.
• 2013 GRF (PI), To develop a microfluidic device for testing allergy. HKD 724,500.
• 2013 AoE (Co-I), Novel wave functional materials for manipulating light and sound. HKD 46.5M.
• 2013 CRF (Co-I), Funtional plasmonics with energy localization for sensing, nano-actuation and optoelectronics. HKD 5,000,000.
• 2013 GRF (Co-I), A novel combination therapy for treating osteoporosis - a mechanistic study on the synergistic bone anabolic effects of HMG CoA reductase inhibitor and Vitamin D. HKD 770769.
• 2013 ITF (Co-I), Establishment of an Intelligent Bio-disc Platform (IBP) for low-cost point-of-care tuberculosis molecular diagnosis. HKD 994,439.
• 2013 HMRF (Co-I), A study on synergistic bone anabolic effects of a combination sse of alendronate and Herba epimedii in treating osteoporosis of ovariectomized Rats. HKD 994,096.
• 2014 ITF (PI), Development of a label-free non-PCR technology for rapid infectious disease diagnosis. HKD 987,050.
• 2014 GRF (Co-I), Lab-in-droplet bioassay strategy with power-enabled lab-on-a-disc. HKD 500,000.
• 2014 HMRF (Co-I), Development & pilot study of monoclonal antibodies for rapid screening of HLA-B*15:02 to enable safer use of carbamazepine. HKD 675,158.
• 2014 UGC Scheme C Funding (Co-I), Establishment of new paradigm with feasible models in teaching & learning science for problem solving & future development. HKD 2,637,000.
• 2014 Vice-Chancellor's One-off Discretionary Fund (Co-I), Functional plasmonics with energy localization for sensing. HKD 2,800,000.
• 2015 HMRF (Co-I), Rapid sample-to-answer smart lab-on-a-disc pharmacogenetic testing device for personalised medicine. HKD 988,328.
• 2016 NSFC/RGC Joint Research Scheme (PI), Investigation of technology and mechanism of in/ex vivo stem-cell differentiation by femtosecond laser. HKD 1,020,000.
• 2017 GRF (Co-I), Hybrid long-range nano-optical tweezers based on plasmonic localisation and photon free trapping with microscale electric thermal heaters. HKD495,846.
• 2019 GRF (Co-I), Deciphering the role of B lymphocytes in liver metabolic homeostasis HKD972,000.
  
  

Patents

• HP Ho, CL Wong, SY Wu, WC Law, Chinlon Lin and SK Kong, Optical sensing devices with SPR sensors based on differential phase interrogation and measuring method using the same, US Patent 7365855 (FULL PATENT, 04/2008).
• HP Ho, SY Wu, C. Lin, SK Kong, Surface plasmon resonance sensors and method for detecting samples using the same, US Patent 7407817 (FULL PATENT, 08/2008).
• SY Wu, HP Ho, YK Suen, SK Kong, WW Wong, KC Lo, Method and Apparatus for Phase Sensitive Surface Plasmon Resonance, US 8169617 (FULL PATENT, 03/2009).
• HP Ho, SY Wu, C. Lin, SK Kong, Surface plasmon resonance sensors and method for detecting samples using the same, US Patent 7892855 (FULL PATENT, 02/2011).
• Chen QL, Ho HP, Kong SK, Kwan PKL, Kwan YW, Kwok HC, Shum P, Suen YK, Wu SY, Yang AKL, Zhou JQ. Microfluidic platform and method for controlling the same. US 20150027555 A1 (FULL PATENT, 01/2015).
• M Tang, HP Ho, G Wang, SK Kong, FC Loo, HC Kwok, SY Wu, X Zhang, Centrifugal Microfluidic Control Systems and Method for Configuring the Same, US. Provisional Patent (Provisional Patent filed, 08/2016).
  
  

Awards

• VC Exemplary Teaching Award (2013)
• Faculty Exemplary Teaching Award (2013)
• RGC Excellent Project 1992-1994