Address

(Office): Room EG07, Science Centre, CUHK

(Lab): Room G95, Science Centre, CUHK

  People FMC

Phone

(Office): (852) 3943 6147

(Lab): (852) 3943 6391
Fax (852) 2603-5646, (852) 2603-5745
Email

This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

1985 PhD (Molecular Biology), The Australian National University, Australia
1980 MPhil (Biology), The Chinese University of Hong Kong, Hong Kong
1978 BSc (Biology), The Chinese University of Hong Kong, Hong Kong

Position

2002 Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong)
1992-2002 Associate Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong)
1988-1992 Research Fellow (Molecular Haematology Group and Medical Molecular Biology Group, The John Curtin School of Medical Research, The Australian National University)
1986-1988 Research Associate (Department of Virology and Epidemidology, Baylor College of Medicine, Houston, USA)

Concurrent Position

  • Adjunct professor of the Soochow University, China
  • Visiting Professor of the First Military Medical University, China
  • Deputy Chief Editor of the "Journal of Tropical Medicine"
  • Editor of the "Chinese Journal of Parasitology and Parasitic Diseases" 

Professional Activities

Appointments in the following Professional Organizations:

  • Chairman of the Hong Kong Society for Immunology (2003-)
  • Organizing Committee of the 11th Annual Conference 2003 of the Hong Kong Institution of Science
  • Organizing member (the International Symposium on "Lymphocytes in Health and Disease") (1995)
  • Session Moderator/Chairman (the International Symposium on "Hypertrophic Scars") (1995)
  • Council member (the Hong Kong Society for Immunology 94/95, 99/01) (1994-95, 1999-2001)

Membership in the following Professional Organizations:

  • American Society for Microbiology
  • Australian Society for Biochemistry and Molecular Biology
  • Australian Society for Immunology
  • Australian Society for Medical Research
  • Australian Society for Parasitology
  • Hong Kong Society for Immunology
  • Hong Kong Institution of Science

Invited Speaker in the following Talk:

  • Soochow University, Nanjing University and Sun Yat-Sen University on: "DNA Vaccine" (Nov 2002)
  • The Hong Kong Society for Immunology on: "Biology of Cytokines and Cytokine Receptors" (1994)
  • The Institute of Biology (Hong Kong Branch) on: "Genetic Engineering in Medicine" (1994)

Research Interests

From Basic to Applied Haematology and Immunology

  1. Discovery of a new drug for treating beta-haemoglobinopathies such as beta-thalassemia and sickle cell anemia (Patent pending, USA)
  2. Development of a multi-epitopic DNA vaccine against Toxoplasma gondii (Patent pending, China)
  3. Host-parasite immunology of Schistosoma japonicum
  4. Cercariae stage specific antigens
  5. Molecular analysis of the acetylcholinesterase and phophatidylinositol glycan-class N, potential drug targets
  6. Immunological studies of the anti-inflammatory protein – Sj16 

Representative Publications

  • Hu, S., Law, P.K., Lv, Z., Wu, Z., Fung, M.C. (2008) Molecular characterization of a calcium-binding protein SjCa8 from Schistosoma japonicum. Parasitology Research DOI: 10.1007/s00436-008-1090-5.
  • Leung, P.S., Lee, Y.S., Tang, C.Y., Kung, W.Y., Chuang, Y.H., Chiang, B.L., Fung, M.C., Chu, K.H. (2008) Induction of Shrimp Tropomyosin-Specific Hypersensitivity in Mice. International Archives of Allergy and Immunology 147: 305-314. [Pub Med]
  • Haritunians, T., Gueller, S., Zhang, L., Badr, R., Yin, D., Xing, H., Fung, M.C., Koeffler, H.P. (2008) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leukemia Research 32: 1366-1373. [Pub Med]
  • Tang, H.L., Lung, H.L., Wu, K.C., Le, A.H., Tang, H.M., Fung, M.C. (2008) Vimentin supports mitochondrial morphology and organization. The Biochemical Journal 410: 141-146. [Pub Med]
  • Lau, K.W., Ren, J., Fung, M.C., Woo, P.C., Yuen, K.Y., Chan, K.K., Qian, P.Y., Wong, P.K., Wu, M. (2007) Fangia hongkongensis gen. nov., sp. nov., a novel gammaproteobacterium of the order Thiotrichales isolated from coastal seawater of Hong Kong. International journal of systematic and evolutionary microbiology 57: 2665-2669. [Pub Med]
  • Tsang, S.L., Leung, P.C., Leung, K.K., Yau, W.L., Hardy, M.P., Mak, N.K., Leung, K.N., Fung, M.C. (2007) Characterization of murine interferon-alpha 12 (MuIFN-alpha12): biological activities and gene expression. Cytokine 37: 138-149. [Pub Med]
  • Li, S.Q., Fung, M.C., Reid, S.A., Inoue, N., Lun, Z.R. (2007) Immunization with recombinant beta-tubulin from Trypanosoma evansi induced protection against T. evansi, T. equiperdum and T. b. brucei infection in mice. Parasite immunology 29: 191-199. [Pub Med]
  • Leung, K.N., Mak, N.K., Fung, M.C. (2005) Cytokines in the differentiation therapy of leukemia: from laboratory investigations to clinical applications. Critical Reviews in Clinical Laboratory Sciences 42: 473-514. [Pub Med]
  • Yue, P.Y., Wong, D.Y., Ha, W.Y., Fung, M.C., Mak, N.K., Yeung, H.W., Leung, H.W., Chan, K., Liu, L., Fan, T.P., Wong, R.N. (2005) Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis 8: 205-216. [Pub Med]
  • Fung, M.C., Sia, S.F., Leung, K.N., Mak, N.K. (2004) Detection of differential expression of mouse interferon-alpha subtypes by polymerase chain reaction using specific primers. Journal of Immunological Methods 284: 177-186 [Pub Med]
  • Mak, N.K., Leung, C.Y., Wei, X.Y., Shen, X.L., Wong, R.N., Leung, K.N., Fung, M.C. (2004) Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells. Biochemical Pharmacology 67: 167-174 [Pub Med]
  • Chen, X.G., Li, H., Peng, H.J., Shen, S.M., Fung, M.C. (2002) Construction and characterization of the cDNA library from Schistosoma japonicum cercariae. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 20: 39-41 [Pub Med]
  • Mak, N.K., Wong, R.N.S., Leung, K.N. and Fung, M.C. (2002) "Involvement of tumor necrosis factor (TNF-) in arsenic trioxide induced apoptic cell death of murine myeloid leukemia cells" Toxicology Letters 135, 79-87.
  • Ming-Chiu Fung, Man-Tat Lau and Xiao-Guang Chen (2002) "Expressed sequence tags (ESTs) analysis of a Schistosoma japonicum cercariae cDNA library" Acta Tropica 82:215-224.
  • Simeonovic, C.J., Townsend, M., Morris, C.F., Hapel, A.J., Fung, M.C., Mann, D.A., Young, I.G., and Wilson, J.D. (1999) "Immune mechanisms associated with the rejection of fetal murine proislet allografts and pig proislet xenografts: Comparison of intragraft cyokine mRNA profiles" Transplantion 67:963-971.
  • Chan, S.C., Fung, M.C., Mak, N.K. and Leung, K.N. (1997) Involvement of interleukin-1 in the differentiation-inducing activity of tumor necrosis factor-a on a murine myeloid leukemia (WEHI-3B JCS). International Journal of Oncology 10:821-826.
  • Mak, N.K., Wong-Leung, Y.L., Chan, S.C., Wen, J., Leung, K.N. and Fung, M.C. (1996) Isolation of anti-leukemia compounds from Citrus reticulata. Life Sciences 58:1269-1276.
  • Morris, C.F., Simeonovic, C.J., Fung, M.C., Wilson, J.D. and Hapel, A.J. (1995) Intragraft expression of cytokine transcripts during pig proislet xenograft rejection and tolerance in mice. Journal of Immunology 154:2470-2482.
  • Mak, N.K., Fung, M.C., Leung, K.N. and Hapel, A.J. (1993) Monocytic differentiation of a myelomonocytic leukemic cell (WEHI-3B JCS) is induced by alpha-tumour necrosis factor. Journal of Immunology 150:1-14.
  • Zola, H., Weedon, H., Thomson, G., Fung, M.C., Ingley, E. and Hapel, A.J. (1991) Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: Effects of activation and differentiation. Immunology 72:167-173.
  • Ingley, E., Cutler, R.L., Fung, M.C., Sanderson, C.L. and Young, I.G. (1991) Production and purification of recombinant human interleukin 5 from yeast and baculovirus expression systems. European Journal of Biochemistry 196:623-629.
  • Fung, M.C., Chiu, K.Y.M., Weber, T., Chang, T.W. and Chang, N.T. (1988) Detection and purification of a recombinant human B lymphotropic virus (HHV6) in the baculovirus expression system by limiting dilution and DNA dot-blot hybridization. Journal of Virological Methods 19:33-42.
  • Campbell, H.D., Ymer, S., Fung, M.C. and Young, I.G. (1985) Cloning and nucleotide sequence of the murine interleukin-3 gene. European Journal of Biochemistry 150:297-304.
  • Hapel, A.J., Fung, M.C., Johnson, R.M., Young, I.G. and Metcalf, D. (1985) Biological properties of molecularly cloned and expressed murine interleukin-3. Blood 65:1453-1459.
  • Fung, M.C., Hapel, A.J., Ymer, S., Cohen, D.R., Johnson, R.M., Campbell, H.D. and Young, I.G. (1984) Molecular cloning of cDNA for murine interleukin-3. Nature 307: 233-237.

Research Grants

Research Grants Council (RGC) Earmarked Grants

2001-2004 Cercariae Stage Specific and Immunogenic Antigen of Schistosoma japonicum - HK$696,000 (Collaborator: Dr XG Chen)
1998-2000 Genetic Immunization against Toxoplasma gondii - HK$645,000 (Collaborators: Dr XG Chen and Dr KN Leung)
1995-1996 Molecular Cloning and Expression of the Helminth Excretory/Secretory Antigen (an Interleukin-5 like Molecule)- HK$531,000 (Collaborator: Dr Nai Ki Mak)
1995-1996 Biochemical and Immunological Characterization of Anti-leukemia drugs Isolated from Citrus species - HK$531,000 (Collaborators: Dr Nai Ki Mak, Dr YL Wong-Leung, and Dr Kwok Nam Leung)
1994-1995 Studies on Cardiovascular, Hepatoprotective and Cytokine Potentiating Activities of the Cultured Mycelial Products of Selected Mushroom Species - HK$743,000 (Collaborators: Dr VEC Ooi, Dr KW Chiu and Dr ST Chang)

Industrial Support Fund 

1995-1997 Biodegradation of Indigo Dye (Cloning of Indigonase Gene and Obtaining a Thermostable Indigonase) - HK$1,320,000 (Collaborators: Dr Albert Y Chang, Dr Kai-Keung Mark, Dr Simon Kwong, Industry Department and the Biotechnology Committee)

WHO Directors's Initiative Fund Research Grant

1999-2000 Construction of the cDNA Library for Schistosoma japonicum cercariae - US$15,000 (Collaborators: Dr XG Chen, XH Zhou, H Li and HJ Peng)

Commonwealth AIDS Research Grant

1991-1992 Effects of Baculovirus Expressed HIV Glycoproteins on Haematopoesis - Aus$ 119,508 (Collaborators: AJ Hapel, and HC O'Neil)

National Health and Medical Research Council

 

1990-1992 The Role of HIV Envelope Glycoproteins in Viral Interference and Immunity - Aus$ 117,365 (Collaborator: AJ Hapel)

Stanley Melbourne Bruce Fund

1988 A Strategy to Combat AIDS - Aus$ 7,000 (Collaborator: AJ Hapel)

Hong Kong University Grant Council (UGC) Direct Grants

2001-2002 Interferon Alpha Subtypes and Antiviral Drugs - HK 24,773
2001-2002 Cloning and expressiogene encoding Sj16, an anti-inflammatory protein from Schistosoma japonicum – HK$20,207
1999-2000 Molecular Analysis of Different Interferon Alpha Subtypes - HK$32,516
1998-1999 The Role of Prostaglandin D Synthase and Prostaglandin D in JCS Cell and Normal Bone Marrow Cell Differentiation - HK$53,107 (Collaborator: Dr NK Mak)
1997-1998 Studies of the Novel Genes Differentially Expressed during Myeloid Cell Differentiation and Embryo Development - HK$33,875
1996-1997 Molecular Cloning of the Chitinase Gene from a Local Fungal Strain - HK$40,000
1995-1996 Isolation of Chitinase Producing Soil Microbes and the Characterization of the Chitinolytic Enzyme - HK$30,000

Direct Grants of the Research Committee, CUHK

1994-1995 Molecular Mechanism of TNF-a Induced Myeloid Leukemia Cell Differentiation - HK$53,000
1993-1994 Molecular Analysis of the Immunoregulatory Effect of the Polysaccharide Bound Protein Complex on the Cytokine Gene Expression - HK$65,000
1992-1993 Molecular Cloning of the Interleukin-5 (a cytokine) Like Molecule from the Helminth Parasite -- Taenia hydatigena (a tapeworm) and Fasicola hepatica (a liver fluke) - HK$100,000

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Address

(Office): Rm E109, Science Centre East Block

(Lab): LG106/108, Run Run Shaw Science Building (RRSSB)

 People GW

Phone

(Office): (852) 3943 6145

(Lab): (852) 3943 1144
Fax (852) 2603 5646
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.bio.cuhk.edu.hk/bio/teaching_staff/ge_ts.htm
 

 

Education

1993 Ph.D. University of Alberta 
1985 M.Sc. Academia Sinica
1982 B.Sc. Nanjing University

Position

  • Professor, School of Life Sciences
  • Director, Cell and Molecular Biology Programme

Research Interests

  • Reproductive biology and endocrinology
  • Paracrine regulation in fish reproductive axis
  • Molecular biology of gonadotropins and their receptors
  • Impact of endocrine disrupting chemicals on fish reproduction and their action mechanisms

Representative Publications

 

  • Zhou R, Tsang AHK, Lau S-W and Ge W. 2011 Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) and Its Receptors in the Zebrafish Ovary – Evidence for Potential Dual Roles of PACAP in Controlling Final Oocyte Maturation. Biology of Reproduction(in press).
  • Yao K and Ge W. 2010 Kit system in the zebrafish ovary - Evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligands (kitlga and kitlgb) during folliculogenesis. Biology of Reproduction82:1216-1226.
  • Liu L and Ge W. 2007 Growth differentiation factor 9 and its spatiotemporal expression and regulation in the zebrafish ovary. Biology of Reproduction76:294-302.
  • Kwok, H.-F., So, W.-K., Wang, Y. and Ge W. 2005 Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors (Fshr and Lhr) - Evidence for their distinct functions in follicle development. Biology of Reproduction72:1370-81.
  • So W-K, Kwok H-F and Ge W. 2005 Zebrafish gonadotropins and their receptors: II. Cloning and characterization of zebrafish follicle-stimulating hormone (FSH) and luteinizing hormone (LH) subunits - Their spatial-temporal expression patterns and receptor specificity. Biology of Reproduction72:1382-96.
  • Wang Y and Ge W. 2004 Developmental profiles of activin βA, βB and follistatin expression in the zebrafish ovary - evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction71:2056-2064.
  • Wang Y and Ge W. 2004 Cloning of epidermal growth factor (EGF) and EGF receptor (EGFR) from the zebrafish ovary and its potential roles in the regulation of ovarian activin/follistatin system. Biology of Reproduction71:749-760.
  • Wang Y, Wong AOL and Ge W. 2003 Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology144:4799-4810.
  • Wang Y and Ge W. 2003 Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin bA and bB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology 144:491-499.
  • Pang Y and Ge W. 2002 Epidermal growth factor (EGF) and transforming growth factor-a (TGF-a) promote zebrafish oocyte maturation in vitro: potential role of the ovarian activin regulatory system. Endocrinology143:47-54.

Research Grants

  • 2009, RGC/GRF A zebrafish story on inhibin, an important reproductive hormone that has been largely ignored in lower vertebrates – Does it serve as an ovarian signal to trigger the brain-pituitary axis for oocyte maturation and ovulation? $1,246,502.
  • 2009, Area of Excellence: Centre for Marine Environmental Research and Innovative Technology Action mechanisms of endocrine disrupting chemicals in fish reproductive axis. $1,000,000.
  • 2008, RGC/GRF Proteomic Analysis of Zebrafish Folliculogenesis Identifies Y-Box Binding Protein 1 (YB-1) in the Primary Growth Follicles – Does YB-1 Play a Gate-keeping Role in Ovarian Follicle Recruitment? $1,292,447.
  • 2008, Focused Investment Scheme C Functional analysis of the brain-pituitary-ovarian axis in the zebrafish and its applications. $1,000,000.
  • 2007, RGC/GRF Functional analysis of pituitary-ovarian axis in the zebrafish – Role of EGFR in LHR signaling in the ovary, a continual story of the intraovarian EGF/EGFR network. $689,996.
  • 2006, RGC/GRF Functional analysis of pituitary-gonadal axis in the zebrafish – Role of growth hormone (GH) in the ovary as both endocrine hormone and paracrine growth factor. $1,203,784.
  • 2005, RGC/GRF Functional analysis of pituitary-gonadal axis in the zebrafish – Why do fish need two gonadotropins, and what is the physiological relevance of FSH? $1,397,914.
  • 2004, RGC/GRF Intrafollicular Communication in the Zebrafish Ovary – Roles of GDF-9 from the oocyte in orchestrating follicle development. $1,321,920.
  • 2002, RGC/GRF Epidermal growth factor (EGF) in the ovary of zebrafish – How is it related to the ovarian activin system in controlling oocyte development? $876,000.
  • 2001, RGC/GRF Activin System in the Pituitary: How Important Is It in the Differential Expression of Fish FSH and LH? $699,600.
  • 1999, RGC/GRF Transcriptional Regulation of Gonadotropin-I and II (GTH-I and II) Genes in the Goldfish by Activin – Functional Analysis of cis-acting Elements that Mediate Activin Stimulation of GTH-Ib and Inhibition of GTH-IIb Expression in the Goldfish, Carassius auratus. $789,000.
  • 1996, RGC/GRF Activin Regulation of Pituitary Gonadotropin Gene Expression and Oocyte Development in Goldfish, Carassius auratus. $865,000.

Awards

  • 2007 The VC’s Exemplary Teaching Award, CUHK
  • 2003 The VC’s Exemplary Teaching Award, CUHK
  • 2007 Exemplary Teaching Award, Faculty of Science, CUHK
  • 2003 Exemplary Teaching Award, Faculty of Science, CUHK
  • 2001 Exemplary Teaching Award, Faculty of Science, CUHK
  • 1996 Biology Society Best Lecturer Award, Department of Biology, CUHK

Professional Activities

  • Associate editor, Frontiers in Experimental Endocrinology
  • Member, The Endocrine Society
  • Member, Society for the Study of Reproduction (SSR)
  • Member, American Association for the Advancement of Science (AAAS)
  • Member, Hong Kong Society of Developmental Biology
  • The Council of the International Federation of Comparative Endocrinological Societies (IFCES) (2009-2013)
  • International Program Committee (IPC) for the 17th International Congress of Comparative Endocrinology (ICCE) (Barcelona, Spain, 2013)
  • International Committee for International Symposium on Fish Endocrinology (ISFE) (2008-)
  • International Advisory Board for the 9th International Symposium on Reproductive Physiology of Fish (ISRPF) (Cochin, India, August 2011)
  • International Advisory Board for the 8th International Symposium on Reproductive Physiology of Fish (ISRPF) (St Malo, France, 3-8 June 2007)
  • International Advisory Board for the 7th International Symposium on Reproductive Physiology of Fish (ISRPF) (Mie, Japan, 18-23 May 2003)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Address

(Office): Room 603B, Mong Man Wai Building
(Lab): Room 611, Mong Man Wai Building

 People MC 

Phone

(Office): (852) 3943 1487
(Lab): (852) 3943 6162
Fax (852) 2603 5646
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web ---
 

 


Education

B.S. (Chemistry)  Harvey Mudd College, Claremont, CA
Ph.D. (Chemistry)  University of California, Berkeley, CA
Postdoctoral Fellow (Protein Crystallography)     California Institute of Technology, Pasadena, CA 


Positions

  • 1995-2001        Assistant Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
  • 2001-2005        Associate Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
  • 2005-2012        Professor of Chemistry/Biochemistry, The Ohio State University, Columbus, OH
  • 2010-2012        Interim-Chair of Biochemistry, The Ohio State University, Columbus, OH
  • 2012-2015        Director, School of Life Sciences, The Chinese University of Hong Kong
  • 2012- Present  Professor, School of Life Sciences, The Chinese University of Hong Kong


Research Interests

  • Chemical Biology -  We are working to capitalize on our discovery of pyrrolysine, the 22nd genetically-encoded amino acid, to engineer proteins with novel structures and properties.
  • Protein crystallography - We wish to use protein crystallography to elucidate the structure function relationships of proteins.
  • Protein Delivery -  We are exploring new technologies to deliver proteins to cells.

 Representative Publications

  1. Yekta, R.; Xiong, X.; Li, J.; Heater, B.S. Lee, M.M.; Chan, M.K.* “Mechano-responsive protein crystals for NADH recycling in multicycle enzyme reactions”, J Am Chem Soc, 2024, 146, 28, 18817. doi:10.1021/jacs.4c04725
  2. Xiong, X.; Heater, B.S.; Ho, W.Y.; Lee, H.K.; Lee, M.M.*; Chan, M.K.* "Genetically encoded multienzyme particles for the biosynthesis of putrescine from L-arginine" ACS Sustainable Chem Eng, 2024, 12, 2, 773–784. doi:10.1021/acssuschemeng.3c05247
  3. Zhang, W.; Yang, Z.; Zheng, J.; Fu, K.; Wong, J.H.; Ni, Y.; Ng, T.B.; Cho, C.H.; Chan, M.K.*; Lee, M.M.* “A bioresponsive genetically encoded antimicrobial crystal for the oral treatment of Helicobacter pylori infection”, Adv Sci, 2023, 10, 2301724. doi:10.1002/advs.202301724
  4. Tai, J.; Wang, L.; Chan, W.S.; Cheng, J.; Chan, Y.H.; Lee, M.M.*; Chan; M.K.* “Pyrrolysine-inspired in cellulo synthesis of an unnatural amino acid for facile macrocyclization of proteins”, J Am Chem Soc, 2023, 145, 18, 10249–10258. doi:10.1021/jacs.3c01291
  5. Li, J.; Kang, P.T.; Jiang, R.; Lee, J.Y.; Soares, J.A.; Krzycki, J.A.*; Chan; M.K.* “Insights from the structures of the pyrrolysine-containing trimethylaminemethyltransferase and its corrinoid protein complex”, Commun Biol, 2023, 16:54. doi:10.1038/s42003-022-04397-3
  6. Li, J.; Wang, L.; Kotaka, M.; Lee, M.M.; Chan; M.K.* "Insights from the structure of an active form of Bacillus thuringiensis Cry5B", Toxins, 2022, 14(12), 823. doi:10.3390/toxins14120823
  7. Yang, Z.; Sun, J.K.; Lee, M.M.*; Chan; M.K.* “Restoration of p53 activity via intracellular protein delivery sensitizes triple negative breast cancer to anti-PD-1 immunotherapy”, J ImmunoTher Cancer, 2022, 10:e005068. doi:10.1136/jitc-2022-005068
  8. Yang, Z.; Yang, M.; Chow, H.-M.; Tsang, S.Y.; Lee, M.M.*; Chan, M.K.* “Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy”, Acta Biomater, 2021, 135, 582-592. doi:10.1016/j.actbio.2021.08.054
  9. Yang, Z.; Lee, M.M.*; Chan, M.K.* “Efficient intracellular delivery of p53 protein by engineered protein crystals restores tumor suppressing function in vivo”, Biomaterials, 2021, 271:120759. doi.org/10.1016/j.biomaterials.2021.120759.
  10. Liang, Z.; Chan, H.Y.E.; Lee, M.M.*; Chan, M.K.* "A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation", Cell Chem Biol, 2021: 28, 180-90. doi:10.1016/j.chembiol.2020.12.010.
  11. Heater, B.S.; Yang, Z.; Lee, M.M.; Chan, M.K.* “In vivo enzyme entrapment in a protein crystal”, J Am Chem Soc, 2020, 142, 9879-9883. doi:10.1021/jacs.9b13462.
  12. Yang, Z.; Heater, B.S.; Cuddington, C.T.; Palmer, A.F.; Lee, M.M.M.*; Chan, M.K.* ”Targeted myoglobin delivery as a strategy for enhancing the sensitivity of hypoxic cancer cells to radiation”, iScience, 2020, 23, 101158. doi:10.1016/j.isci.2020.101158.
  13. Yang, Z.; Zheng, J.; Chan, C.-F.; Wong, I.L.K.; Heater, B.S.; Chow, L.M.C.; Lee, M.M.*; Chan, M.K.* “Targeted delivery of antimicrobial peptide by Cry protein crystal to treat intramacrophage infection”, Biomaterials, 2019, 217:119286. doi:10.1016/j.biomaterials.2019.119286.
  14. Heater, B.S.; Chan, W.S.; Lee, M.M.; Chan, M.K.* “Directed evolution of a genetically-encoded immobilized lipase for the efficient production of biodiesel from waste cooking oil”, Biotechnol Biofuels, 2019, 12: 165. doi:10.1186/s13068-019-1509-5.
  15. Li, X.*; Fekner, T.*; Ottesen, J.J.; Chan, M.K.* “A pyrrolysine analog for site-specific protein ubiquitination”, Angew Chem, 2009, 48, 9184-7.
  16. Fekner, T.; Li, X.; Lee, M.M.; Chan, M.K.* “A pyrrolysine analog for protein click chemistry”, Angew Chem, 2009, 48, 1633-5.
  17. Gong, W.*; Hao, B.*; Wei, Z.; Ferguson, D.J. Jr.; Tallant, T.; Krzycki, J.A.*; Chan, M.K.* “Structure of the CODH component of the M. barkeri ACDS complex”, Proc Natl Acad Sci USA, 2008, 105, 9558-63.
  18. Blight, S.K.; Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E. Zhao, G., Kang, P., Green-Church, K.B., Chan, M.K., Krzycki, J.A.* “Direct charging of tRNACUA with pyrrolysine in vitro and in vivo”, Nature, 2004, 431, 333-5. (cited in Nature, C&E News)
  19. Hao, B., Gong, W., Ferguson, T.K., James, C.M., Krzycki, J.A.*, Chan, M.K.* “Identification of novel UAG encoded residue: structure of a methanogen methyltransferase”, Science, 2002, 296, 1462-1466. (cited in C&E News, Nature, Science, CNN Headline News, Reuters)
  20. Gong, W.* Hao, B., Mansy, S.S., Gonzalez, G. Gilles-Gonzalez, M.A.*, Chan, M.K.* “Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction”, Proc. Natl. Acad. Sci. USA, 1998, 95, 15177-15182.


Research Grants

  1. 2024-2027, HKEX Research Funding Scheme (Co-I, PI: M.M. Lee), “Developing the next generation biocatalysts for the sustainable production of bio-based polyamide precursors towards the preservation of our natural environment”
  2. 2024-2025, Innovation and Technology Fund, “Facile synthesis and incorporation of proximity reactive amino acids for the generation of improved protein therapeutics”
  3. 2023-2024, Innovation and Technology Fund, “Pos3Aa platform-mediated Intracellular delivery of tumor suppressors to potentiate immunotherapy for immunologically cold tumors”
  4. 2022-2025, Health and Medical Research Fund (Co-I, PI: M.M. Lee), “Improving the therapeutic index of melittin to eradicate drug-resistant Acinetobacter baumannii”
  5. 2022-2025, Research Grants Council GRF, “In vivo synthesis and site-specific incorporation of pyrrolysine analogs for the facile generation of cyclic peptides and modified proteins”
  6. 2022-2024, Research Grants Council GRF, “Engineered Cry3Aa crystals for improved antimicrobial peptide delivery against intramacrophage infections”
  7. 2021-2024, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "Bioengineering arginine decarboxylase as a new therapeutic for cancer treatment”
  8. 2021-2023, Innovation and Technology Fund, “SUMO-derived peptide inhibitors for treating synucleinopathies”
  9. 2021-2023, Innovation and Technology Fund, (Co-I, PI: Y.P. Ho) “Development of a micro shear porator for loading red blood cells with therapeutic proteins”
  10. 2020-2022, Research Grants Council GRF, “Structural Studies of pyrrolysine-containing Methyltransferases”
  11. 2020-2021, Innovation and Technology Fund, “A versatile platform for generating recyclable catalysts for the production of biodiesel and commodity chemicals”
  12. 2019-2022, Research Grants Council GRF, “Genetically-encoded immobilized lipases for biofuel production”
  13. 2018-2021, Research Grants Council GRF, “Structural studies of nematicidal Cry proteins”
  14. 2017-2025, Research Grants Council AOE Grant (Co-PI, PI: Yang), “Chemical biology approach to molecular medicine”
  15. 2017-2019, Research Grants Council GRF, "Immobilized lipases for biodiesel conversion"
  16. 2016-2018, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "A novel anti-microbial crystal for the treatment of Helicobacter pylori infection"
  17. 2016-2019, Research Grants Council GRF, "Exploring the potential of myoglobin as an anti-cancer agent"
  18. 2015-2017, Health and Medical Research Fund, "Biological crystal subunit vaccines for mycobacterial diseases"
  19. 2015-2018, Research Grants Council GRF, “Studies of a copper peptide complex that can mediate methane oxidation”
  20. 2013-2015, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 10: “Novel dawadawa therapy for intestinal helminthic infections”
  21. 2012-2014, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 9: “A new system for dual bacterial/insecticidal crop protection”


Awards

Lando-SOHIO Fellowship, University of Minnesota (1984), Sigma Xi (1986), Phi-Lambda Upsilon (1986), Regents Fellowship, University of California (1986), Amoco Foundation Fellowship in Chemistry (1991), NIH Postdoctoral Fellowship (1992-1994), NSF Career Award (2000), Alfred P. Sloan Fellowship (2000), Member, NIH Study Section-BMT (2002-2006), Mr. and Mrs. Sun Chan Award in Organic Chemistry (2002), Visiting Scholar of the National Research Council of the Republic of China (2002), OSU College of Biological Sciences Award for Research and Graduate Education (2004), Visiting Scholar of the National Research Council of the Republic of China (2005, 2011), Japan Society for Promotion of Science Fellowship (2006), OSU Distinguished Scholar Award (2009), S. Y. Chung Visiting Fellow of New Asia College, CUHK (2010), Fellow of the American Association for the Advancement of Science (2011), Cynthia Anne Chan Memorial Lecturer, UC Berkeley (2011), RGC Physical Science Panel (2011, Chair 2012).


Others

We currently have openings for a postdoc having a degree from either a Hong Kong or Top 100 University. Those interested should contact us 3 months before the target start date.

We are also currently recruiting highly motivated graduate students with prior publications and/or exceptional academic records who are competitive for the Hong Kong Postgraduate fellowship Scheme. Please contact us by Nov 1 for consideration.

 

 

 

Address

(Office): Rm 384, Science Centre South Block
(Lab): LG 101 & 103, Run Run Shaw Science Building

 People JLW2 

Phone

(Office): (852) 3943 6388
(Lab): (852) 3943 6379
Fax (852) 2603 5745
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web

http://www.cuhk.edu.hk/centre/iCell/

http://www.cuhk.edu.hk/centre/ccdb/
   


Education

1996  Ph.D. Simon Fraser University
1992 M.Sc. University of British Columbia
1984 B.Sc. South China Agricultural University


Position

  • Choh-Ming Li Professor of Life Sciences, School of Life Sciences, CUHK
  • Director, Cell and Molecular Biology (CMB) Program, CUHK
  • Director, Centre for Cell and Developmental Biology, CUHK
  • Director, RGC-AoE "Centre for Organelle Biogenesis and Function", CUHK
  • Director, Institute of Plant Molecular Biology and Agricultural Biotechnology (IPMBAB), CUHK 


Research Interests

  • Plant Cell and Molecular Biology
  • Protein Targeting and Trafficking in Plant Cells
  • Organelle Biogenesis and Function in Plants
  • Plant Bioreactors for Pharmaceutical Proteins


Representative Publications

  1. Ye H, Gao J, Liang Z, Lin Y, Yu Q, Huang S and *Jiang L (2022) The Arabidopsis ORP2A Mediates ER-Autophagosomal Membrane Contact Sites and Regulates PI3P in Plant Autophagy. PNAS 119(43):e2205314119.
  2. Niu F, Ji C, Liang Z, Guo R, Chen Y, Zeng Y and *Jiang L (2022) ADP-ribosylation factor D1 modulates Golgi morphology, cell plate formation, and plant growth in Arabidopsis. Plant Physiology 190(2):1199-1213.
  3. He Y, Gao J, Luo M, Gao C, Lin Y, Wong HY, Cui Y, Zhuang X and *Jiang L (2022) VAMP724 and VAMP726 are involved in autophagosome formation in Arabidopsis thaliana. Autophagy (in press) doi: 10.1080/15548627.2022.2127240.
  4. Li B, Zeng Y, Lo SW, Guo Y and *Jiang L (2022) In vitro reconstitution of COPII vesicles from Arabidopsis thaliana suspension cultured cells. Nature Protocols (in press).
  5. Huang S, Liu Z, Cao W, Li H, Zhang W, Cui Y, Hu S, Luo M, Zhu Y, Zhao Q, Xie L, Gao C, Xiao S and *Jiang L (2022) The plant ESCRT component FREE1 regulates peroxisome-mediated turnover of lipid droplets in germinating Arabidopsis seedlings. Plant Cell (in press) doi: 10.1093/plcell/koac195.
  6. Cao W, Li Z, Huang S, Shi Y, Zhu Y, Lai MN, Lok PL, Wang X, Cui Y and *Jiang L (2022) Correlation of vacuole morphology with stomatal lineage development by whole-cell electron tomography. Plant Physiology 188(4):2085-2100.
  7. Li B, Zeng Y, Cao W, Zhang W, Cheng L, Yin H, Wu Q, Wang X, Huang Y, Lau WCY, Yao ZP, *Guo Y and *Jiang L (2021) A Distinct Giant COPII Vesicle Population in Arabidopsis thaliana. Nature Plants 7(10):1335-1346.
  8. * Zeng Y, Li B, Ji C, Feng L, Niu F, Deng C, Chen S, Lin Y, Cheung KCP, Wong KB and *Jiang L  (2021) A unique AtSar1D-AtRabD2a nexus modulates autophagosome biogenesis in Arabidopsis thaliana. PNAS 118(17):e2021293118.
  9. Lin Y, Zeng Y, Zhu Y, Shen J, Ye H and *Jiang L  (2021) Plant Rho GTPase signaling promotes autophagy. Molecular Plant 14(6):905-920.
  10. Liu Z, Gao J, Cui Y, Klumpe S, Erdmann PS and *Jiang L  (2021) Membrane Imaging in the Plant Endomembrane System. Plant Physiology 185:562-576.
  11. Ji CY, Zhou J, Guo R, Lin Y, Kung CH, Hu S, Ng WY, Zhuang XH and *Jiang L (2020) AtNBR1 is a selective autophagic receptor for AtExo70E2 in Arabidopsis. Plant Physiology 84(2):777-791.
  12. *Zhao Q, Shen J, Gao C, Cui Y, Wang Y, Cui J, Cheng L, Cao W, Zhu Y, Huang S, Zhou Q, Leong CK, Leung KP, Chen X and *Jiang L (2019) RST1 is a FREE1 suppressor that negatively regulates vacuolar trafficking in Arabidopsis. Plant Cell 31(9):2152-2168.
  13. Li H, Li Y, Zhao Q, Li T, Wei J, Li B, Shen W, Yang C, Zeng Y, Rodriguez P, Zhao Y, *Jiang L, *Wang X and *Gao C (2019) The Plant ESCRT Component FREE1 Shuttles to the Nucleus to Attenuate Abscisic Acid Signalling. Nature Plants 5(5):512-524.
  14. * Cui Y, Cao W, He Y, Zhao Q, Wakazaki M, Zhuang X, Gao J, Zeng Y, Gao C, Ding Y, Wong HY, Wong WS, Lam HK, Wang P, Ueda T, Rojas-Pierce M, Toyooka K, Kang BH and *Jiang L (2019) A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells. Nature Plants 5(1):95-105.
  15. *Shen J, Zhao Q, Wang X, Gao C, Zhu Y, Zeng Y and *Jiang L (2018) A Plant Bro1 Domain Protein BRAF Regulates Multivesicular Body Biogenesis and Membrane Protein Homeostasis. Nature Communications 9(1):3784.

Research Grants

  • 2022-2026, RGC Senior Research Fellow Scheme (SRFS), "Cellular and Molecular Characterization of the Tip-Vesicles in Germinating Pollen Tube", HK$ 7,798,380
  • 2021-2024, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “Vacuole Biogenesis, Dynamics and Functions in Plants” HK$ $6,400,000
  • 2020-2023, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong”, HK$7,439,308
  • 2019-2024, Research Grants Council (RGC) Research Impact Fund (RIF) as PI “Plant Bioreactor for Pharmaceutical Proteins”, HK$5,000,000
  • 2018-2021, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “Molecular Mechanisms of Autophagy and Autophagosome in Plants”, HK$7,209,550
  • 2017-2020, Research Grants Council (RGC) Collaborative Research Fund (CRF) as PC “The First Integrated cryo-EM and cryo-ET Shared Facility for Life Sciences Research in Hong Kong”, HK $9,500,000
  • 2014-2021, Research Grants Council (RGC) Areas of Excellence Scheme (AoE) Grant as PC “Center for organelle biogenesis and function”, HK$47,250,000


Awards

  • 2021: RGC Senior Research Fellowship (2021/22)
  • 2017: Higher Education Outstanding Scientific Research Output Awards 2017 Second Class Prize, Ministry of Education of PRC
  • 2016: Research Excellence Award 2015-16, CUHK
  • 2015: Croucher Senior Research Fellowship 2015-2016, The Croucher Foundation
  • 2014: Choh-Ming Li Professor of Life Sciences, CUHK
  • 2014: Higher Education Outstanding Scientific Research Output Awards 2013 Second Class Prize, Ministry of Education of PRC
  • 2010: Higher Education Outstanding Scientific Research Output Awards 2009 First Class Prize, Ministry of Education of PRC
  • 2013: Outstanding Fellow of the Faculty of Science, CUHK
  • 2009: The Croucher Senior Research Fellowship 2009-2010
  • 2009: Research Excellence Award 2009-10, CUHK
  • 2008: Exemplary Teaching Award 2008, Faculty of Science, CUHK
  • 2006: Research Excellence Award 2006-07, CUHK


Professional Activities

  • Editor-in-Chief: Plant Science
  • Senior Editor: Journal of Integrative Plant Biology and 植物学报
  • Associate Editor: Protoplasma and Frontiers in Plant Science
  • Editorial Board: Plant Cell; Molecular Plant and 中國科學: 生命科學


Awards Received by Graduate Students and Postdoc

  • Young Scientist Award in Life Science, Hong Kong Institution of Science, 2021 (Li Baiying)
  • 1000 Young Talent Program of China, 2019 (Cui Yong)
  • 1000 Young Talent Program of Zhejiang, 2017 (Shen Jinbo)
  • 1000 Young Talent Program of China, 2015 (Ding Yu, Gao Caiji)
  • CUHK Young Scholars Thesis Award 2013 (Zhuang Xiaohong)
  • CUHK Young Scholars Dissertation Award 2013  (Shen Jinbo)
  • CUHK Young Scholars Dissertation Award 2009 (Miao Yansong)
  • Postgraduate Research Output Award 2016, CUHK (Zeng Allen)
  • Postgraduate Research Output Award 2013, CUHK (Shen Jinbo)
  • Postgraduate Research Output Award 2009, CUHK (Miao Yansong)
  • Postgraduate Research Output Award 2006, CUHK (Lam Sheung Kwan)
  • Postgraduate Research Output Award 2004, CUHK (Tse Yu Chung)
  • Research Fellowship Scheme 2018-2019, CUHK (Zeng Yonglun)
  • Research Fellowship Scheme 2017-2018, CUHK (Cui Yong)
  • Research Fellowship Scheme 2016-2017, CUHK (Cui Yong)
  • Research Fellowship Scheme 2015-2016, CUHK (Shen Jinbo)
  • Research Fellowship Scheme 2014-2015, CUHK (Zhuang Xiaohong)
  • Research Fellowship Scheme 2013-2014, CUHK (Ding Yu)
  • Keystone Symposium Scholarship 2012 (Wang Juan)
  • Keystone Symposium Scholarship 2007 (Miao Yansong)
  • The HFSP (Human Frontier Science Program) Long-Term Fellows 2010 (Lam Sheung Kwan)
  • The HFSP (Human Frontier Science Program) Long-Term Fellows 2009 (Miao Yansong)

Faculty Positions Lab Alumni

  • Hu Shuai, Associate Professor, Zhejiang Agriculture and Forestry University
  • Lau Wilson Chun Yu, Assistant Professor, CUHK
  • Cui Yong, Professor, Xiamen University
  • Zhao Qiong, Professor, East China Normal University
  • Shen Jinbo, Professor, Zhejiang Agriculture and Forestry University
  • Wang Xiangfeng, Associate Professor, China Agricultural University
  • Zhuang Xiaohong, Assistant Professor, CUHK
  • Wang Juan, Associate Professor, South China Agricultural University
  • Gao Caiji, Professor, South China Normal University
  • Ding Yu, Professor, Jinan University
  • Wang Hao, Professor, South China Agricultural University
  • Miao Yansong, Nanyang Assistant Professor, Nanyang Technological University
  • Cai Yi, Professor, Sichuan Agricultural University
  • Tse Yu Chung, Associate Professor, South University of Science and Technology of China
  • Wang Junqi, Associate Professor, South University of Science and Technology of China
  • Mo Beixin, Professor, Shenzhen University
  • Li Hongye, Professor, Jinan University

Address

(Office): Rm 138, Science Centre North Block
(Lab): --

 People PKS
 

Phone

(Office): (852) 3943 1393
(Lab): --
Fax

(852) 2603 6510
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web --
 

 

Education

Ph.D. Yale University
B.S. University of Washington

 

Position

  • Lecturer, School of Life Sciences


Research Interests

  • Immunology
  • Innate activation of adaptive immunity
  • Pathogen recognition by innate receptors
  • Influenza virus infection
  • Immune regulation by commensal bacteria


Representative Publications

  • Li L., Leung A.K., Kwok T.P., Lai Y.Y.Y., Pang I.K., Chung G.T., Mak A.C.Y., Poon A., Chu C., Li M., Wu J.J.K., Lam E.T., Cao H., Lin C., Sibert J., Yiu S.M., Xiao M., Lo K.W., Kwok P.Y., Chan T.F., Yip K.Y. (2017). OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps. Genome Biol. 18(1):230.
  • Schmid E.T., Pang I.K., Carrera Silva E.A., Bosurgi L., Miner J.J., Diamond M.S., Iwasaki A., Rothlin C.V. (2016). AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife. 5:e12414.
  • Pillai P.S., Molony R.D., Martinod K., Dong H., Pang I.K., Tal M.C., Solis A.G., Bielecki P., Mohanty S., Trentalange M., Homer R.J., Flavell R.A., Wagner D.D., Montgomery R.R., Shaw A.C., Staeheli P., Iwasaki A. (2016). Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 352(6284):463-6.
  • Pang, I.K., Pillai, P.S., and Iwasaki, A. (2013). Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I. Proc Natl Acad Sci U S A. 110(34), 13910-5.
  • Pang, I.K., Ichinohe, T., and Iwasaki, A. (2013). IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus. Nature immunology 14, 246-253.
  • Pang, I.K., and Iwasaki, A. (2012). Control of antiviral immunity by pattern recognition and the microbiome. Immunological Reviews 245, 209-226.
  • Ichinohe, T.*, Pang, I.K.*, Kumamoto, Y., Peaper, D.R., Ho, J.H., Murray, T.S., and Iwasaki, A. (2011). Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A 108(13), 5354-5359. *, authors contributed equally to this work
  • Pang, I.K., and Iwasaki, A. (2011). Inflammasomes as mediators of immunity against influenza virus. Trends in immunology 32, 34-41.
  • Ichinohe, T., Pang, I.K., and Iwasaki, A. (2010). Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nature immunology 11, 404-410.

 
Awards

  • Faculty Exemplary Teaching Award, Faculty of Science, CUHK, 2016
  • Distinguished Doctoral Dissertation, Yale University Graduate School of Arts and Sciences, 2013
  • Distinguished Speaker Award, Yale University Microbial Diversity Institute Symposium, 2012
  • Keystone Symposia Travel Scholarship, 2011
  • Amgen Scholars Alumni Travel Award, 2011

 
Professional Activities

  • Speaker, “Taking brakes off Immune System to attack Cancer”, Popular Science Special Lecture Series: How Nobel Prizes Are Won, Faculty of Science, CUHK, 2018
  • Speaker, “Ebola: The Micro-Killer”, The 11th Lau Oi Wah Memorial Science Lecture Series, Faculty of Science, CUHK, 2015
  • Invited Speaker, 6th HKU-Pasteur Immunology Course for Research Postgraduate Students, 2013
  • Invited Workshop Presenter, Keystone Symposia Conference on Pathogenesis of Influenza, 2011