Professor LEUNG Lai Kwok

Address

(Office): Rm 507C, Mong Man Wai Building
(Lab): Rm 507D, Mong Man Wai Building

 People LLK
 

Phone

(Office): (852) 3943 8137
(Lab): (852) 3943 8072
Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web

http://www.bch.cuhk.edu.hk/lkleung/
 

 

 

Education

  Ph.D. in Nutritional Science, University of Kentucky
  M.Sc. in Food Science and Human Nutrition, University of Wyoming
  B.Sc. in Food Science, University of Alberta


Position

  • 1999 – present Assistant and Associate Professor, Food and Nutritional Sciences Programme,
    Chinese University of Hong Kong
  • 1995 – 1999 Postdoctoral Fellow, NCI-Frederick and University of Maryland


Research Interests

  •  Food Toxicology 


Representative Publications

(Total 66 journal articles & 8 abstracts)

  1. Li F, Wong TY, Lin S-M, Chow S, Cheung W-H, Chan FL, Chen S, Leung LK. (2014) Co-administrating luteolin minimizes the side effects of the aromatase inhibitor letrozole. Journal of Pharmacology and Experimental Therapeutic (accepted).
  2. Wong TY, Lin S-M, Poon CH, Leung LK. (2014) The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. Chemico-Biological Interactions Sep;221:70-76.
  3. Wang Y, Wong TY, Chan FL, Chen S, Leung LK. (2014) Assessing the effect of food myco-toxins on aromatase by using a cell-based system. Toxicology In Vitro Jun;28(4):640-6.
  4. Wong TY, Li F, Lin S-M, Chan FL, Chen S, Leung LK. (2014) Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. BMC Cancer Jun 12;14:426.
  5. Wang Y, Li L, Wang CC, Leung LK. (2013) Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae. Toxicology 314(1): 148–154.
  6. Tan W, Wong TY, Wang Y, Huang J, Leung LK. (2013) CYP19 Expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Molecular and Cellular Endocrinology 375(1-2):106-112.
  7. Tan W, Huang H, Wang Y, Wong TY, Wang CC, Leung LK. (2013) Bisphenol A differentially activates protein kinase C isoforms in murine placental tissue. Toxicology and Applied Pharmacology 269(2):163-168.
  8. Wang Y, Tan W, Leung LK. (2013) Zeranol upregulates corticotrophin-releasing hormone expression in the placental cell line JEG-3. Toxicology Letters 219(3):218-222.
  9. Li FJ, Chow S, Cheung W-H, Chan FL, Chen S, Leung LK. (2013) The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer. Journal of Nutritional Biochemistry Jun;24(6):1112-6.
  10. Poon CH, Wong TY, Wang Y, Tsuchiya Y, Nakajima M, Yokoi T, Leung LK. (2013)The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonizing XRE-binding. British Journal of Nutrition 109:1598-1605.


Research Grants

  • Establishing the Citrus Flavonoid Hesperetin as a Natural Alternative to Aromatase Inhibitor Direct Grants HK$38,742 Apr 30, 2011-Apr 30, 2012
  • Pharmacological properties of the licorice flavonoid isoliquiritigenin RGC Earmarked Grant HK$598,500 Jan 1, 2007-Dec 31, 2008


Professional Activities

Manuscript Reviewer
2003-present
Journal of Nutrition, British Journal of Nutrition, Toxicological Sciences, Toxicology in Vitro, BBA-Molecular Cell Research, Molecular Nutrition and Food Research, Nutrition and Cancer, Cancer Letters, BMC Cancer, Cell Biology and Toxicology, Journal of Pharmacy and Pharmacology, Journal of Agricultural and Food Chemistry, Journal of Food Biochemistry.

Grant Reviewer
2004-5, 2010 Cancer Research UK