Professor ZHUANG Xiaohong

Address

(Office): Rm 181, Science Centre (South), CUHK
(Lab): Rm LG105, Run Run Shaw Science Building, CUHK

 People ZhuangXiaohong 23

Phone

(Office): (852) 3943 4066
(Lab): (852) 3943 8963
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web https://sites.google.com/view/zhuang-lab/home


Education

  • BSc, Sun Yat-sen University
  • MPhil-PhD, The Chinese University of Hong Kong


Position

  • Assistant Professor, School of Life Sciences, The Chinese University of Hong Kong


Research Interests

  • Autophagy and autophagosome formation in plants and green algae
  • Selective autophagy in plant stress response
  • Lipid metabolism and membrane dynamics


Representative Publications (*Corresponding author, #Co-first author)

  1. Zhuang X. #*, Li R. #*, and Jiang L. #* (2024) A Century Journey of Organelles Research in the Plant Endomembrane System. Plant Cell. https://doi.org/10.1093/plcell/koae004
  2. Luo M#, Law KC#, He Y#, Chung KK, Po MK, Feng L, Chung KP, Gao C, Zhuang, X. * and Jiang L.* (2023) Arabidopsis AUTOPHAGY-RELATED (ATG) 2 is essential for ATG18a and ATG9 trafficking during autophagosome closure. Plant Physiology. 193(1), 304-321.
  3. He Y, Gao J, Luo M, Gao C, Lin Y, Wong HY, Cui Y, Zhuang, X., Jiang L. (2023). VAMP724 and VAMP726 are involved in autophagosome formation in Arabidopsis thaliana. Autophagy 19(5):1406-1423.
  4. Zhou, J., Ma, J., Yang, C., Zhu, X., Li, J., Zheng, X., Li, X., Chen, S., Feng, L., Wang, P., Ho, M. I., Ma, W., Liao, J., Li, F., Wang, C., Zhuang, X., Jiang, L., Kang, B. H., & Gao, C. (2023). A non-canonical role of ATG8 in Golgi recovery from heat stress in plants. Nature Plants, 9(5), 749-765.
  5. Li H, Huang R, Liao Y, Yang S, Feng B, Qin H, Zhou J, Zeng Y, Shen J, Zhuang, X., Jiang L, Otegui MS, Zhang S, Gao C. (2023) A plant-unique protein BLISTER coordinates with core retromer to modulate endosomal sorting of plasma membrane and vacuolar proteins. Proc Natl Acad Sci U S A. 120(1):e2211258120.
  6. Li, H., Liao, Y., Zheng, X., Zhuang, X., Gao, C., Zhou, J. (2022). Shedding Light on the Role of Phosphorylation in Plant Autophagy. FEBS Lett. 596(17):2172-2185.
  7. Law, K.C., Chung, K.K., and Zhuang, X. * (2022). An update on coat protein complexes for vesicle formation in plant post-Golgi trafficking. Front Plant Sci. 13, 826007.
  8. Sun S, Feng L, Chung KP, Lee KM, Cheung HHY, Luo M, Ren K, Law KC, Jiang L, Wong KB, Zhuang X. * (2021) Mechanistic insights into an atypical interaction between ATG8 and SH3P2 in Arabidopsis thaliana. Autophagy 18, 1350-1366.
  9. Zhang, X.#, Man, Y. #, Zhuang, X. #, Shen, J. #, Zhang, Y., Cui, Y., Yu, M., Xing, J., Wang, G., Lian, N., Hu, Z., Ma, L., Shen, W., Yang, S., Xu, H., Bian, J., Jing, Y., Li, X., Li, R., Mao, T., Jiao, Y., Sodmergen, Ren, H., and Lin, J. (2021). Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques. Sci China Life Sci 64, 1392-1422.
  10. Yang C., Luo M., Zhuang X., Li F., and Gao C. (2020). Transcriptional and Epigenetic Regulation of Autophagy in Plants. Trends in Genetics 36: 676-688.
  11. Zhuang, X. *, Chung, K.P. #, Luo Mengqian and Jiang, L*. (2018) Autophagosome Biogenesis and the Endoplasmic Reticulum: A plant perspective. Trends in Plant Science 23:677-692
  12. Zhuang, X., Chung, K.P. and Jiang, L. (2017) Targeting tail-anchored proteins into plant organelles. Proc Natl Acad Sci U S A 114:1762-1764.
  13. Zhuang, X. #, Chung, K.P. #, Cui, Y. #, Lin, W., Gao, C., Kang, Y.B., and Jiang, L. (2017) ATG9 Regulates Autophagosome Progression from the Endoplasmic Reticulum in Arabidopsis. Proc Natl Acad Sci U S A 114: E426-E43
  14. Soto-Burgos J.#, Zhuang X. #, Jiang L and Bassham C.D. (2017) Dynamics of autophagosome formation. Plant Physiology 176:219-229
  15. Gao C.#, Zhuang X. #, Shen J and Jiang L. (2017) Plant ESCRT complexes: moving beyond endosomal sorting. Trends in Plant Science. 22:986-998
  16. Gao C. #, Zhuang X. #, Cui Y., Fu X., He Y., Zhao Q., Zeng Y., Shen J., Luo M., and Jiang L. (2015). Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Proc Natl Acad Sci U S A 112, 1886-1891.
  17. Zhuang X. #, Cui, Y. #, Gao, C., and Jiang, L. (2015). Endocytic and autophagic pathways crosstalk in plants. Current Opinion in Plant Biology 28, 39-47.
  18. Cai, Y.#, Zhuang X. #, Gao, C. #, Wang, X. #, and Jiang, L. (2014). The Arabidopsis Endosomal Sorting Complex Required for Transport III Regulates Internal Vesicle Formation of the Prevacuolar Compartment and Is Required for Plant Development. Plant Physiology 165, 1328-1343
  19. Li, S., Liu, L., Zhuang X., Yu, Y., Liu, X., Cui, X., Ji, L., Pan, Z., Cao, X., Mo, B., Zhang, F., Raikhel, N., Jiang, L., and Chen, X. (2013). MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 153, 562-574.
  20. Zhuang X. #, Wang, H. #, Lam, S.K., Gao, C., Wang, X., Cai, Y., and Jiang, L. (2013). A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis. Plant Cell 25, 4596-4615.


Research grants

  • 2024-2026  Research Grants Council General Research Fund (GRF), Molecular Characterization of Novel ATG8-interacting Proteins in Plant Autophagy, PI
  • 2024-2025  Research Grants Council (RGC) Germany/Hong Kong Joint Research Scheme, Membrane Remodeling by Biomolecular Condensates in Plant Autophagosome and Vacuole, PI
  • 2023-2025  NSFC Excellent Young Scientists Fund (Hong Kong and Macau), Molecular Mechanism of Membrane Trafficking in Plant Autophagy, PI
  • 2023-2025  Research Grants Council (RGC) General Research Fund (GRF), Investigating the roles of autophagy in organelle homeostasis in the unicellular green alga Chlamydomonas, PI
  • 2021-2024  NSFC/RGC Joint Research Scheme 2020/21, Molecular Mechanism Study of the Reciprocal Regulation of SnRK1 Kinase and Plant Autophagy, PI
  • 2021-2023  Research Grants Council (RGC) Early Career Scheme (ECS), Molecular mechanism of SH3P2 in plant autophagy and mitochondrial pathway, PI
  • 2018-2021  Research Grants Council (RGC)  Germany/Hong Kong Joint Research Scheme, Intersection Points of Autophagy and Ubiquitination, PI
  • 2022-2025  Research Grants Council (RGC) Collaborative Research Fund (CRF), The First Integrated State-of-the-Art Live Cell Imaging Platforms to Timely Promote Interdisciplinary and Advanced Life Sciences Research in Hong Kong and Beyond, Co-PI
  • 2021-2024  Research Grants Council (RGC) Collaborative Research Fund (CRF), Vacuole Dynamics, Biogenesis and Functions in Plants, Co-PI
  • 2021-2023  Research Grants Council (RGC) Collaborative Research Fund (CRF), The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong, Co-PI
  • 2019-2024  Research Grants Council (RGC) Research Impact Fund (RIF), Plant Bioreactor for Pharmaceutical Proteins, Co-PI
  • 2018-2021  Research Grants Council (RGC) Collaborative Research Fund (CRF), Molecular Mechanisms of Autophagy and Autophagosome in Plants, Co-PI

 
Awards

  • 2022   Higher Education Outstanding Scientific Research Output Awards 2022, Second Class Prize (Natural Sciences, 6/10), Ministry of Education, China
  • 2022   China’s Excellent Young Scientists Fund (Hong Kong and Macau)
  • 2022   Association of Applied Biologists (AAB) Travel Grant
  • 2019   American Society of Plant Biologists (ASPB) Travel Grant
  • 2017   Higher Education Outstanding Scientific Research Output Awards 2017, Second Class Prize (Natural Sciences, 3/7), Ministry of Education, China
  • 2013   The Chinese University of Hong Kong Yong Scholars Thesis Awards


Professional Activities

  • Review editor: Nature communications, Molecular Plant, PNAS, The Plant Cell, Plant physiology, New phytologist, Frontiers in Plant Science (Plant Cell Biology), Plant Science, Bio-protocol and Protoplasma
  • H1 Connect Associate Faculty Member (Formerly Faculty Opinions)