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Education

Position

• Lecturer, School of Life Sciences

Research Interests

• Molecular and cellular neuroscience
• Cell signaling and gene regulation 

Representative Publications

• Siow, N.L., Choi, R.C., Xie, H.Q., Kong, L.W., Chu, G.C., Chan, G.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2010) ATP Induces Synaptic Gene Expressions in Cortical Neurons: Transduction and Transcription Control Via P2Y1 Receptors. Mol. Pharmacol.78:1059-1071.
• Doctor, B.P., Tsim, K.W. and Siow, N.L. (2008) The IXth International Meeting on Cholinesterases, Suzhou, People's Republic of China, 6 to 10 May 2007. Chem. Biol. Interact.175:1-2. (Preface of the conference proceedings)
• Xie, H.Q., Choi, R.C., Leung, K.W., Siow, N.L., Kong, L.W., Lau, F.T., Peng, H.B. and Tsim, K.W. (2007) Regulation of a transcript-encoding the proline rich membrane anchor (PRiMA) of globular muscle acetylcholinesterase: the suppressive roles of myogenesis and innervating nerves. J. Biol. Chem.282:11765-75.
• Siow, N.L., Xie, H.Q., Choi, R.C. and Tsim, K.W. (2005) ATP induces the post-synaptic gene expression in neuron-neuron synapses: Transcriptional regulation of AChE catalytic subunit. Chem Biol Interact.157-158:423-426.
• Tung, E.K., Choi, R.C., Siow, N.L., Jiang, J.X., Ling, K.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2004) P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Mol. Pharmacol.66:794-806.
• Ling, K.K., Siow, N.L., Choi, R.C., Ting, A.K., Kong, L.W. and Tsim, K.W. (2004) ATP potentiates agrin-induced AChR aggregation in cultured myotubes: activation of RhoA in P2Y1 nucleotide receptor signaling at vertebrate neuromuscular junctions. J. Biol. Chem.279(30):31081-31088.
• Lee, H.H., Choi, R.C., Ting, A.K., Siow, N.L., Jiang, J.X., Massoulie, J. and Tsim KW. (2004) Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. J. Biol. Chem.279(26):27098-27107.
• Jiang, J.X., Choi, R.C., Siow, N.L., Lee, H.H., Wan, D. C. and Tsim, K.W. (2003): Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP–dependent signaling. J. Biol. Chem.278:45435-45444.
• Choi, R.C., Siow, N.L., Ling, K.K., Cheng, A.W., Tung, E.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2003): ATP acts through the P2Y1 receptor to enhance the expression of muscle acetylcholinesterase and acetylcholine receptors: transduction pathways and control of transcription. J. Neurosci.23:4445-4456.
• Siow, N.L., Choi, R.C., Cheng, A.W., Jiang, J.X., Wan, D.C., Zhu, S.Q. and Tsim, K.W. (2002) A cyclic AMP-dependent pathway regulates the expression of acetylcholinesterase during myogenic differentiation of C2C12 Cells. J. Biol. Chem. 277: 36129-36136.