Professor CHEN Zhenyu

Address

(Office): Rm 179, Science Centre South Block
(Lab): Rm 194, Science Centre South Block

 People ZYC 

Phone

(Office): (852) 3943 6382
(Lab): (852) 3943 8141
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
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Education

1989 Ph. D. University of Massachusetts
1982 B. Sc. Henan Normal University

Position

  • Research Professor, School of Life Sciences, CUHK

Research Interests

  • Food Chemistry and Nutrition
  • Fat and cholesterol metabolism and heart diseases

Representative Publications

  1. Yan C, Huang SH, Ding HF, Kwek E, Liu JH, Chen ZX, Ma KY, Chen ZY. 2023. Adverse effect of oxidized cholesterol exposure on colitis is mediated by modulation of gut microbiota. Journal of Hazard Materials. 459:132057
  2. Wang WW, Yang WJ, Dai Y, Liu JH, Chen ZY. 2023. Production of Food-Derived Bioactive Peptides with Potential Application in Management of Diabetes and Obesity: A Review. Journal of Agricultural and Food Chemistry. 71, 15, 5917–5943
  3. Chook, CYB, Cheung YM, Ma KY, Leung FP, Zhu H, Niu QJ, Wong WT, Chen ZY. 2023. Physiological concentration of protocatechuic acid directly protects vascular endothelial function against inflammation in diabetes through Akt/eNOS pathway. Frontiers in Nutrition 2023.1060226.
  4. Kwek E, Yan C, Ding H, Hai W, He Z, Ma KY, Liu J, Zhu H, Chen ZY. 2022 Effect of thermally oxidized oil (Corn oil and Lard) on gut microbiota in hamsters. Antioxidants. 11(9): 1732
  5. Kwek E, Yan C, Ding H, Hao W, He Z, Liu J, Ma KY, Zhu H, Chen ZY. 2022. Effects of hawthorn seed oil on plasma cholesterol and gut microbiota. Nutrition and Metabolism. 19:55
  6. Yan C, Kwek E, Ding H, He Z, Ma KY, Zhu H, Chen ZY. 2022. Dietary Oxidized Cholesterol Aggravates Chemically Induced Murine Colon Inflammation and Alters Gut Microbial Ecology. Journal of Agricultural and Food Chemistry. 70(41):13289-13301.
  7. Guo Z, Pan J, Zhu H, Chen ZY. 2022. Metabolites of Gut Microbiota and Possible Implication in Development of Diabetes Mellitus. Journal of Agricultural and Food Chemistry. 270 (20): 5945–5960.
  8. Kwek E, Zhu H, Ding H, He Z, Hao W, Liu J, Ma KY, Chen Z. 2022. Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters. European Journal of Nutrition. 61(5):2341-2356.
  9. Liu J, Hao W, He Z, Kwek E, Zhu H, Ma N, Ma KY, Chen ZY. 2021. Blueberry and Cranberry Anthocyanin Extracts Reduce Body weight and Modulate Gut Microbiota in C57BL/6J Mice Fed with a High-Fat Diet. European Journal of Nutrition DOI:1007/s00394-020-02446-3.
  10. Yip PSP, Chan TFJ, He Z, Leung LK, Leung SFS, Chen ZY. 2020. Quantification of breast milk trans fatty acids and trans fat intake by Hong Kong lactating women. European Journal of Clinical Nutrition. 74(5) 765-774.
  11. Liu J, Hao W, He Z, Kwek E, Zhao Y, Zhu H, Liang N, Ma KY, Lei L, He WS, Chen ZY. Beneficial effects of tea water extracts on the body weight and gut microbiota in C57BL/6J mice fed with a high-fat diet. Food & Function. 10:2847-2860.
  12. Zhu H, He Z, Kwek E, Liu J, Hao W, Liang N, Zhao Y, Ma KY, He WS, Chen ZY. 2018. Dose-dependent increases in liver cholesterol but not plasma cholesterol from consumption of one to five whole eggs and no effects from egg whites on liver or plasma cholesterol in hamsters. Journal of Agricultural and Food Chemistry. 66: 12805-12814.
  13. Wang X, Guan L, Zhao Y, Lei L, Liu Y, Ma KY, Wang L, Man SW, Wang J, Huang, Chen ZY. 2015. Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters. Atherosclerosis 242:77-86.
  14. Chen J, Jiang Y, Liang Y, Tian XY, Peng C, Ma KY, Liu J, Huang Y, Chen ZY. 2012. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet, Atherosclerosis 221:397– 404.
  15. Jiao R, Zhang Z, Yu H, Huang Y, Chen ZY. Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1, Journal of Nutritional Biochemistry 2010, 21,1134-1139.
  16. Cao Y, Chen J, Yang L and Chen ZY. Differential incorporation of dietary conjugated linolenic acid and linoleic acids into milk lipids and liver phospholipids in lactating and suckling rats, Journal of Nutritional Biochemistry 2009, 20, 685-693.
  17. Zhang ZS, Wang H, Jiao R, Peng C, Wong YM, Yeung VSY, Huang Y, Chen ZY. Choosing Hamsters but not Rats as a Model for Studying plasma cholesterol-lowering Activity of Functional Foods, Molecular Nutrition & Food Research 2009, 53,921-930.
  18. Li YM, Chan HYE, Yao XQ, Huang Y, Chen ZY. Green Tea Catechins and Broccoli Reduce Fat-Induced Mortality in Drosophila melanogaster, Journal of Nutritional Biochemistry 2008, 19,376-383.

Research Grants

  • 2024-2027, GRF, Dietary Fructose Increases whereas Dietary Polyphenols Decreases Intestinal Villus Length: A Mechanism Study with Application of Weight Management. HK$ 1,583,300.
  • 2023-2026, GRF, Why Is the Absorption of Cholesterol and Plant Sterol Selective? HK$ 1,1390,894.
  • 2022-2025, GRF, Does dietary oxidized cholesterol alter gut microbiota and is it more atherosclerotic than dietary cholesterol itself? Amount: HK$ 1,120,000.
  • 2021-2024, GRF, Dietary polyphenols and their gut metabolite protocatechuic acid: mechanism of cardiovascular benefits and interaction with microbiota, HK$1,179,577.
  • 2017-2019, HMRF, Quantification of breast milk trans fatty acids and trans fat intake by Hong Kong Lactating Women, HK$813,385.
  • 2016-2018, HMRF, Management of hypercholesterolemia using tartary buckwheat: Research on active ingredients and underlying mechanism, HK$1,065,332.
  • 2013-2015, GRF, Effect of Dietary Sesamin on cholesterol absorption and cholesterol homeostasis: A mechanism study , HK$ 952,636.
  • 2014-2017, GRF, Why do cholesteryl ester (CE) species differently elevate plasma cholesterol level- A mechanism study, HK$1,068,250
  • 2008-2011, GRF, Dietary Calcium deficiency and inadequacy elevate blood cholesterol level: a mechanism study, HK$649,765.
  • 2007-2010, GRF, Why does dietary oxidized cholesterol elevate blood cholesterol level more effectively than non-oxidized cholesterol? HK$932,500.
  • 2005-2008, GRF, Effect of linoleic acid (LA), conjugated linoleic acid (CLA), alpha-linolenic acid (LN) and conjugated linolenic acid (CLN) on blood cholesterol: a mechanism study, HK$568,957.
  • 2004-2006, GRF, Effect of selective estrogen receptor modulators on coronary artery reactivity in cholesterol-fed, ovariectomized rabbits, HK$939,968.
  • 2000-2003, GRF, Hypolipidemic and antioxidant activity of theaflavins and thearubigins from oolong and black tea, HK$763,200.
  • 1997-2000, GRF, Investigation of mechanisms of cholesterol-lowering effect of green tea epicatechin isomers, HK$ 1,122,000.
  • 1995-1998, GRF, Metabolic fate of trans/cis fatty acids in high-trans milk and their effect on metabolism of essential fatty acids, HK$ 1,180,000.
  • 1996-1998, Wei Lun Foundation, Identification and evaluation of biologically active compounds present in Chinese green tea, HK$ 835,000.

Patents

  • Wang J et al. Patent ZL 200510074259.1 (China patent) and HK 1095288 (Hong Kong), Formulations for Menopausal Syndromes.
  • 楊林，陳振宇，曹瑩，高紅麗，陳競男，基於酶促法合成共軛亞油酸甘油酯類衍生 物，公開號：CN101200741，申請號：CN200610156502
  • 楊林，陳振宇，曹瑩。基於酶促法合成共軛亞油酸糖酯類衍生物， 公開號： CN101386875，申請號：CN200710145415

 Awards

  • Medal of Honor (MH), HKSAR Government, 2024.
  • Fellow of Royal Society of Chemistry, 2015.
  • Fellow of American Chemical Society-Division of Agricultural and Food Chemistry 2012
  • American Chemical Society (ACS) Advancement of Application of Agricultural and Food Chemistry Award, 2016.
  • Research Excellence Award 2008-2009, Chinese University of Hong Kong
  • Natural Science Research Award (2nd Prize), Ministry of Education, China
  • T.K. Murray Postdoctoral Research Fellowship Award, 1992, National Institute of Nutrition, Canada.

Professional Activities

  • Associate Editor, Journal of Agricultural and Food Chemistry.
  • Associate Editor, Food Reviews International.
  • Advisory Board Member, Food & Function.
  • Editorial Board Member, Journal of Functional Foods
  • Editorial Board Member, Food Science and Human Wellness.
  • Editorial Board Member, Biomedical and Environmental Sciences.
  • Editorial Board Member, Journal of Food Chemistry and Nutrition.
  • Editorial Board Member, Acta Nutrimenta Sinica
  • Editorial Board Member, Open Agriculture Journal
  • Editorial Board Member, Parkinstan Journal of Nutrition
  • Editorial Board Member, Food Science (China)
  • Council member, China Nutrition Society
  • Academic Advisor, Hong Kong Nutrition Association